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No association between AKT1 polymorphism and schizophrenia: A case-control study in a Korean population and a meta-analysis

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dc.contributor.authorLee, Kyu Young-
dc.contributor.authorJoo, Eun-Jeong-
dc.contributor.authorJeong, Seong Hoon-
dc.contributor.authorKang, Ung Gu-
dc.contributor.authorKim, Se Hyun-
dc.contributor.authorHwang, Jae Yeon-
dc.contributor.authorLee, Namyoung-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorAhn, Yong Min-
dc.contributor.authorKim, Su-Gyeong-
dc.contributor.authorSong, Joo Yun-
dc.contributor.authorRoh, Myoung-Sun-
dc.date.accessioned2012-07-04T04:42:52Z-
dc.date.available2012-07-04T04:42:52Z-
dc.date.issued2010-03-
dc.identifier.citationNEUROSCIENCE RESEARCH; Vol.66 3; 238-245ko_KR
dc.identifier.issn0168-0102-
dc.identifier.urihttps://hdl.handle.net/10371/78396-
dc.description.abstractV-akt murine thymoma viral oncogene homolog 1 (AKT1) has been suggested to be involved in the pathophysiology of schizophrenia Recent, independent studies in Caucasian, Japanese, Iranian, and Chinese populations have reported that the AKT1 gene may be associated with schizophrenia, but these results have yet to be replicated in other populations. In the present study, we performed a case-control association study between AKT1 and schizophrenia in a Korean population. We genotyped six single nucleotide polymorphisms (SNP1 (rs3803300), SNP2 (rs1130214), SNP3 (rs3730358), SNP4 (rs1130233), SNP5 (rs2494732), SNP A (rs2498804)) of AKT1, selected froth previous reports, in a sample of 283 subjects with schizophrenia and 350 controls. No significant difference in single marker polymorphisms or haplotype frequencies of the six SNPs in the AKT1 gene was observed between controls and subjects with schizophrenia In addition, we carried out an updated meta-analysis of the six SNPs, and found no evidence for an association between the six SNPs and schizophrenia Taken together, our results do not support the hypothesis that AKT1 is a susceptibility gene for schizophrenia (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society All rights reservedko_KR
dc.description.sponsorshipThis study was supported by a grant from the Korea Healthcare
Technology R&D Project, Ministry for Health, Welfare and Family
Affairs (A030001), and by National Research Foundation of Korea
Grant funded by the Korean Government (2009-0076274).		ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectAKT1ko_KR
dc.subjectKoreanko_KR
dc.subjectAssociationko_KR
dc.subjectPolymorphismko_KR
dc.subjectMeta-analysisko_KR
dc.subjectSchizophreniako_KR
dc.titleNo association between AKT1 polymorphism and schizophrenia: A case-control study in a Korean population and a meta-analysisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이규영-
dc.contributor.AlternativeAuthor주은정-
dc.contributor.AlternativeAuthor정성훈-
dc.contributor.AlternativeAuthor강웅구-
dc.contributor.AlternativeAuthor노명선-
dc.contributor.AlternativeAuthor김세현-
dc.contributor.AlternativeAuthor송주윤-
dc.contributor.AlternativeAuthor황재연-
dc.contributor.AlternativeAuthor김수경-
dc.contributor.AlternativeAuthor이남영-
dc.contributor.AlternativeAuthor안용민-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.1016/j.neures.2009.11.005-
dc.citation.journaltitleNEUROSCIENCE RESEARCH-
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dc.description.tc4-
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