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Smart Magnetic Fluorescent Nanoparticle Imaging Probes to Monitor MicroRNAs
DC Field | Value | Language |
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dc.contributor.author | Hwang, Do Won | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Kim, Soonhag | - |
dc.date.accessioned | 2012-07-04T06:11:42Z | - |
dc.date.available | 2012-07-04T06:11:42Z | - |
dc.date.issued | 2010-01-04 | - |
dc.identifier.citation | SMALL; Vol.6 1; 81-88 | ko_KR |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78428 | - |
dc.description.abstract | An imaging system that can be used to evaluate the expression levels of microRNAs during neuronal development can provide noninvasive information for investigating a variety of biological phenomena related to microRNAs (miRNAs, miRs). Herein, the development of a novel imaging platform to monitor intracellular miR124a during neuronal differentiation is reported using rhodamine-coated cobalt ferrite magnetic fluorescent (MF) nanoparticles linked to a quenching molecular system containing an miR124a binding sequence (MF-miR124a beacon). During neuronal differentiation, in vitro fluorescence signals of the MF-miR124a beacon are significantly increased under conditions where miR124a is highly expressed, and dramatically return to the original quenched fluorescence after anti-miR124a treatment. In vivo fluorescence images show enhanced fluorescence signals in mice with P19 cells within a poly-L-lactic acid scaffold after induction of neuronal differentiation. In addition, magnetic resonance (MR) images provide in vivo tracking of cells containing the MF-miR124a beacon. These studies represent the first step toward the use of nanotechnological imaging of mature miRNA, and this technique could be used for cellular tracking with a MR imaging system as well as for simultaneous monitoring of the miRNA expression pattern in vivo. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-V C H VERLAG GMBH | ko_KR |
dc.subject | fluorescence | ko_KR |
dc.subject | imaging | ko_KR |
dc.subject | nanoparticles | ko_KR |
dc.subject | RNA | ko_KR |
dc.subject | molecular beacons | ko_KR |
dc.title | Smart Magnetic Fluorescent Nanoparticle Imaging Probes to Monitor MicroRNAs | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 황도완 | - |
dc.contributor.AlternativeAuthor | 송인찬 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 김순학 | - |
dc.identifier.doi | 10.1002/smll.200901262 | - |
dc.citation.journaltitle | SMALL | - |
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dc.description.tc | 7 | - |
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