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Changes in heart rate dynamics of patients with schizophrenia treated with risperidone

Cited 29 time in Web of Science Cited 32 time in Scopus
Authors
Chang, Jae Seung; Yoo, Cheol Sung; Yi, Sang Hoon; Hong, Kye Hyun; Oh, Hong Seok; Kim, Yong Sik; Ahn, Yong Min; Jung, Dong Chung; Lee, Yu-Sang
Issue Date
2010-08-16
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 6; 924-929
Keywords
Heart rate variabilityRisperidoneSympathovagal balanceSchizophrenia
Abstract
Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naive or medication-free patients with DSM-IV schizophrenia completed electrocardiogram (ECG) assessments at baseline and after six weeks of treatment with risperidone. Indices of HRV were extracted from 5-min resting ECG recordings and compared to those obtained from control subjects matched for age and gender. Psychiatric and drug-induced extrapyramidal symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Drug-Induced Extrapyramidal Symptoms Scale (1DIEPSS). In comparison with matched controls, patients with acute schizophrenia showed lower values of time-domain measures, lower high-frequency power (HF) and a higher ratio of low to high frequency (LF/HF). In the within-subject analyses, a significant decrease in LF/HF was associated with risperidone treatment. In addition, LF/HF, which initially co-clustered with clinical variables, congregated with other HRV measures after the six-week risperidone treatment. These results indicate that, in the therapeutic process, risperidone treatment may exert a beneficial influence on the sympathovagal imbalance in acute schizophrenia. (C) 2010 Elsevier Inc. All rights reserved.
ISSN
0278-5846
Language
English
URI
http://hdl.handle.net/10371/78437
DOI
https://doi.org/10.1016/j.pnpbp.2010.04.017
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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