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Functional Reorganization Associated with Semantic Language Processing in Temporal Lobe Epilepsy Patients after Anterior Temporal Lobectomy : A Longitudinal Functional Magnetic Resonance Image Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae-Hun | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kang, Eunjoo | - |
dc.contributor.author | Kim, June Sic | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Song, In Chan | - |
dc.date.accessioned | 2012-07-04T06:40:50Z | - |
dc.date.available | 2012-07-04T06:40:50Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY; Vol.47 1; 17-25 | ko_KR |
dc.identifier.issn | 2005-3711 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78439 | - |
dc.description.abstract | Objective : The focus of this study is brain plasticity associated with semantic aspects of language function in patients with medial temporal lobe epilepsy (mTLE). Methods : Using longitudinal functional magnetic resonance imaging (fMRI), patterns of brain activation were observed in twelve left and seven right unilateral mTLE patients during a word-generation task relative to a pseudo-word reading task before and after anterior temporal section surgery. Results : No differences were observed in precentral activations in patients relative to normal controls (n = 12), and surgery did not alter the phonological-associated activations. The two mTLE patient groups showed left inferior prefrontal activations associated with semantic processing (word-generation > pseudo-word reading), as did control subjects. The amount of semantic-associated activation in the left inferior prefrontal region was negatively correlated with epilepsy duration in both patient groups. Following temporal resection, semantic-specific activations in inferior prefrontal region became more bilateral in left mTLE patients, but more left-lateralized in right mTLE patients, The longer the duration of epilepsy in the patients, the larger the increase in the left inferior prefrontal semantic-associated activation after surgery in both patient groups. Semantic activation of the intact hippocampus, which had been negatively correlated with seizure frequency, normalized after the epileptic side was removed. Conclusion : These results indicate alternation of semantic language network related to recruitment of left inferior prefrontal cortex and functional recovery of the hippocampus contralateral to the epileptogenic side, suggesting an intra- and inter-hemispheric reorganization following surgery. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN NEUROSURGICAL SOC | ko_KR |
dc.subject | fMRI | ko_KR |
dc.subject | Hippocampus | ko_KR |
dc.subject | Brain plasticity | ko_KR |
dc.subject | Language | ko_KR |
dc.subject | Epilepsy | ko_KR |
dc.title | Functional Reorganization Associated with Semantic Language Processing in Temporal Lobe Epilepsy Patients after Anterior Temporal Lobectomy : A Longitudinal Functional Magnetic Resonance Image Study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김재훈 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 강은주 | - |
dc.contributor.AlternativeAuthor | 김전식 | - |
dc.contributor.AlternativeAuthor | 송인찬 | - |
dc.contributor.AlternativeAuthor | 정천기 | - |
dc.identifier.doi | 10.3340/jkns.2010.47.1.17 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | - |
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dc.description.tc | 1 | - |
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