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A combination treatment with SAHA and ad-p63/p73 shows an enhanced anticancer effect in HNSCC

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dc.contributor.authorShim, Seon-Hui-
dc.contributor.authorLee, Choon-Taek-
dc.contributor.authorLee, Jae-Jung-
dc.contributor.authorKim, So-Yeon-
dc.contributor.authorHeo, Dae Seog-
dc.contributor.authorSung, Myung-Whun-
dc.contributor.authorHah, J. Hun-
dc.date.accessioned2012-07-04T06:58:16Z-
dc.date.available2012-07-04T06:58:16Z-
dc.date.issued2010-12-
dc.identifier.citationTUMOR BIOLOGY; Vol.31 6; 659-666ko_KR
dc.identifier.issn1010-4283-
dc.identifier.urihttp://hdl.handle.net/10371/78446-
dc.description.abstractSuberoylanilide hydroxamic acid (SAHA) is one of the most widely used histone deacetylase inhibitors. However, the potential advantage of SAHA has not been sufficiently validated as an adjunct to gene therapy of head and neck squamous cell carcinoma (HNSCC). SAHA has been shown to boost the efficiency of gene transfer by upregulating the expression of coxsackie adenoviral receptor on treated cells. The p53 family genes, p63 and p73, have been shown to have characteristics similar to p53, and although they are not confirmed as tumor suppressors, DNA-damaging signals induce their overexpression. We previously reported that the adenovirus-mediated transfer of p63 or p73 showed an effective cancer-killing effect similar to that of p53. In this study, we combined SAHA with adenoviral delivery of p63 or p73 to enhance the efficiency of gene therapy. This combination resulted in a significantly enhanced cancer-killing effect in HNSCC cell lines but had no effect on normal human fibroblasts. SAHA treatment added to ad-p63/p73 gene delivery caused an increase in p21 expression and cleaved poly-ADP ribose polymerase. Our results indicate that adjuvant SAHA treatment could be developed as a therapeutic strategy to enhance the efficiency of adenoviral gene transfer in the treatment of cancer.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectCombination gene therapyko_KR
dc.subjectp73ko_KR
dc.subjectSAHAko_KR
dc.subjectHNSCCko_KR
dc.subjectp63ko_KR
dc.titleA combination treatment with SAHA and ad-p63/p73 shows an enhanced anticancer effect in HNSCCko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor심선휘-
dc.contributor.AlternativeAuthor이춘택-
dc.contributor.AlternativeAuthor이재정-
dc.contributor.AlternativeAuthor김소연-
dc.contributor.AlternativeAuthor허대석-
dc.contributor.AlternativeAuthor성명훈-
dc.identifier.doi10.1007/s13277-010-0083-z-
dc.citation.journaltitleTUMOR BIOLOGY-
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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