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MRI study of the cavum septum pellucidum in obsessive-compulsive disorder
DC Field | Value | Language |
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dc.contributor.author | Chon, Myong-Wuk | - |
dc.contributor.author | Choi, Jung-Seok | - |
dc.contributor.author | Kang, Do-Hyung | - |
dc.contributor.author | Jung, Myung Hun | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.date.accessioned | 2012-07-04T07:59:58Z | - |
dc.date.available | 2012-07-04T07:59:58Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; Vol.260 4; 337-343 | ko_KR |
dc.identifier.issn | 0940-1334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78476 | - |
dc.description.abstract | The cavum septum pellucidum (CSP), a putative marker of neurodevelopmental anomaly, has been associated with an increased risk of several psychiatric disorders. The purpose of this study was to evaluate the CSP in patients with obsessive-compulsive disorder (OCD) compared with healthy control subjects. Seventy-one patients with OCD and 71 healthy volunteers matched for age and sex were evaluated with magnetic resonance imaging. We evaluated the CSP using criteria employed in previous studies: presence of the CSP, length of the CSP, and overall size of the CSP, measured in five grades, ranging from grades 0 (no CSP) to 4 (severe CSP). We evaluated OCD symptom severity using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). The CSP presence was significantly greater in the OCD group (60.6%) than in control subjects (29.6%), and CSP size grade was significantly larger in the OCD group (chi(2) = 15.609, P = 0.004). CSP length showed no significant group difference. Among patients with OCD, those with a CSP had higher scores on the obsession subscale of the Y-BOCS than those without a CSP (Z = -2.358, P = 0.018), while they did not show significant difference from those without a CSP in the compulsion subscale of the Y-BOCS, age, duration of illness, or age at onset. These results indicate that neurodevelopmental alterations in midline structures might contribute to the pathogenesis of OCD. | ko_KR |
dc.description.sponsorship | This paper was supported by a Grant
(M103KV010012-08K2201-01210) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER HEIDELBERG | ko_KR |
dc.subject | Cavum septum pellucidum | ko_KR |
dc.subject | Obsessive-compulsive disorder | ko_KR |
dc.subject | Magnetic resonance imaging | ko_KR |
dc.title | MRI study of the cavum septum pellucidum in obsessive-compulsive disorder | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 천명욱 | - |
dc.contributor.AlternativeAuthor | 최정석 | - |
dc.contributor.AlternativeAuthor | 강도형 | - |
dc.contributor.AlternativeAuthor | 정명훈 | - |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.identifier.doi | 10.1007/s00406-009-0081-6 | - |
dc.citation.journaltitle | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | - |
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dc.description.tc | 0 | - |
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