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Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity

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dc.contributor.authorShin, Hyun-Woo-
dc.contributor.authorHan, Doo Hee-
dc.contributor.authorLim, Yune Sung-
dc.contributor.authorKim, Hye Jung-
dc.contributor.authorLee, Chul Hee-
dc.contributor.authorRhee, Chae-Seo-
dc.contributor.authorMin, Yang-Gi-
dc.contributor.authorKim, Dong-Young-
dc.date.accessioned2012-07-05T00:33:37Z-
dc.date.available2012-07-05T00:33:37Z-
dc.date.issued2009-10-
dc.identifier.citationOTOLARYNGOLOGY-HEAD AND NECK SURGERY; Vol.141 4; 442-447ko_KR
dc.identifier.issn0194-5998-
dc.identifier.urihttp://hdl.handle.net/10371/78520-
dc.description.abstractOBJECTIVE: To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloprotemase (TIMP-1) in nasal polyposis. STUDY DESIGN: A case-control study. SETTING: A tertiary referral center. SUBJECTS AND METHODS: The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosm staining were also performed and those expression levels were compared. RESULTS: Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group. CONCLUSION: The presence of AR may enhance the expression of MAV-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherMOSBY-ELSEVIERko_KR
dc.titleNonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivityko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor신현우-
dc.contributor.AlternativeAuthor한두희-
dc.contributor.AlternativeAuthor임윤성-
dc.contributor.AlternativeAuthor김혜정-
dc.contributor.AlternativeAuthor김동영-
dc.contributor.AlternativeAuthor이철희-
dc.contributor.AlternativeAuthor민양기-
dc.contributor.AlternativeAuthor이재서-
dc.identifier.doi10.1016/j.otohns.2009.07.011-
dc.citation.journaltitleOTOLARYNGOLOGY-HEAD AND NECK SURGERY-
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dc.description.tc5-
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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