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Up-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shock

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dc.contributor.authorRoh, Myoung-Sun-
dc.contributor.authorCui, Feng Ji-
dc.contributor.authorAhn, Yong Min-
dc.contributor.authorKang, Ung Gu-
dc.date.accessioned2012-07-05T01:51:26Z-
dc.date.available2012-07-05T01:51:26Z-
dc.date.issued2009-10-
dc.identifier.citationNEUROSCIENCE RESEARCH; Vol.65 2; 210-213ko_KR
dc.identifier.issn0168-0102-
dc.identifier.urihttps://hdl.handle.net/10371/78551-
dc.description.abstractCocaine- and amphetamine-regulated transcript (CART) peptide regulates appetite, reward, and mood. CART expression is regulated via the protein kinase A (PKA) pathway, and electroconvulsive shock (ECS), an efficient antipsychotic and antidepressant measure, activates PKA-related signaling. Thus, we hypothesized that ECS may regulate the expression of CART. ECS given daily for five consecutive days increased CART mRNA and protein in the rat nucleus accumbens (NAc), accompanied by an increase in CREB phosphorylation. Our results suggest that ECS-induced CART up-regulation might be associated with PKA-CREB signaling, but the causal direction remains to be elucidated in future studies. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.ko_KR
dc.description.sponsorshipThis study was supported by a grant (KRF-2005-04-E00233)
from the Korean Research Foundation and a research fund by Shin
Hae Choi (2002) from the Korean Neuropsychiatric Association.		ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectCARTko_KR
dc.subjectElectroconvulsive shockko_KR
dc.subjectNucleus accumbensko_KR
dc.subjectDepressionko_KR
dc.subjectCREBko_KR
dc.titleUp-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shockko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor노명선-
dc.contributor.AlternativeAuthor안용민-
dc.contributor.AlternativeAuthor강웅구-
dc.identifier.doi10.1016/j.neures.2009.06.013-
dc.citation.journaltitleNEUROSCIENCE RESEARCH-
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dc.description.tc3-
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