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The Effect of Neontal MK-801 Treatment on ERK1/2-p70S6K-S6 Signal Pathway and Protein Synthesis Rate in the Frontal Cortex of Developing Rat Brain
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- Authors
- Issue Date
- 2009-04-15
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- BIOLOGICAL PSYCHIATRY; Vol.65(8); 42S-42S
- Abstract
- Background: Treatment of MK-801, a selective NMDA receptor antagonist, on
neonatal rat induces long-term neurochemical and behavioral changes, which
is suggested as the neurodevelopmental rat model of schizophrenia. Proper
regulation of protein synthesis is required for neurodevelopment process.
- ISSN
- 0006-3223
- Language
- English
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