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Cell cycle regulators, APC/β-catenin, NF-κB and Epstein-Barr virus in gastric carcinomas
DC Field | Value | Language |
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dc.contributor.author | Kim, Bomi | - |
dc.contributor.author | Byun, Sun-Ju | - |
dc.contributor.author | Kim, Young A. | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.date.accessioned | 2012-07-10T01:28:36Z | - |
dc.date.available | 2012-07-10T01:28:36Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | PATHOLOGY; Vol.42(1); 58-65 | ko_KR |
dc.identifier.issn | 0031-3025 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78682 | - |
dc.description.abstract | Aims: To evaluate the clinicopathological value of cell cycle regulators, the Writ pathway, the NF-beta B pathway and Epstein-Barr virus (EBV) and to assess their relationships in gastric carcinoma. Methods: We investigated cell cycle regulators (p53, p21, Rb), APC, beta-catenin and NF-kappa B using immunohistochemistry and EBV using in situ hybridisation for EBV encoded small RNAs in 117 cases of gastric carcinoma. Results: p53 overexpression was more frequently observed in advanced gastric carcinoma and lymph node metastasis than in early carcinoma or in the absence of metastasis (p < 0.05). p21 loss was positively correlated with APC loss, but inversely correlated with beta-catenin nuclear accumulation and NF-kappa B positivity (p < 0.05). EBV positive gastric carcinomas were located in the upper third of the stomach, and more were of the diffuse or mixed types than the EBV negative group (p < 0.05). EBV infection was positively correlated with p21 loss and APC loss and inversely correlated with beta-catenin alteration (p < 0.05). In multivariate analysis, patient age, TNM stage and p53 were independent prognostic factors for gastric carcinoma. Conclusions: p53 status is a prognostic marker for gastric carcinoma. p21, APC, beta-catenin and NF-kappa B may be functionally interrelated in gastric carcinogenesis. Loss of p21 and APC may be involved in the carcinogenesis of EBV positive gastric carcinomas. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | TAYLOR & FRANCIS LTD | ko_KR |
dc.subject | p53 | ko_KR |
dc.subject | Epstein-Barr virus | ko_KR |
dc.subject | stomach neoplasm | ko_KR |
dc.subject | prognosis | ko_KR |
dc.subject | NF-κB | ko_KR |
dc.subject | p21 | ko_KR |
dc.subject | APC | ko_KR |
dc.subject | β-catenin | ko_KR |
dc.title | Cell cycle regulators, APC/β-catenin, NF-κB and Epstein-Barr virus in gastric carcinomas | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김보미 | - |
dc.contributor.AlternativeAuthor | 변선주 | - |
dc.contributor.AlternativeAuthor | 김영아 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 장미수 | - |
dc.identifier.doi | 10.3109/00313020903356392 | - |
dc.citation.journaltitle | PATHOLOGY | - |
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