Publications
Detailed Information
Glycogen synthase kinase-3β does not correlate with the expression and activity of β-catenin in gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Yu-Jin | - |
dc.contributor.author | Yoon, Jiyeon | - |
dc.contributor.author | Ko, Young-San | - |
dc.contributor.author | Kim, Sue-Youn | - |
dc.contributor.author | Kim, Woo-Ho | - |
dc.contributor.author | Youn, Hong-Duk | - |
dc.contributor.author | Lee, Byung-Lan | - |
dc.contributor.author | Kim, Ji-Hun | - |
dc.contributor.author | Park, Jong-Wan | - |
dc.contributor.author | Cho, Sung-Jin | - |
dc.date.accessioned | 2012-07-10T04:19:21Z | - |
dc.date.available | 2012-07-10T04:19:21Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | APMIS; Vol.118(10); 782-790 | ko_KR |
dc.identifier.issn | 0903-4641 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78693 | - |
dc.description.abstract | The regulation of beta-catenin activation by glycogen synthase kinase-3 beta (GSK-3 beta) in cancer has been shown to be cell type-specific. This study was performed to investigate the relationship between activated GSK-3 beta (phosphorylated at Tyr216) and beta-catenin in gastric cancer. Immunohistochemical tissue array analysis of 278 human gastric carcinoma specimens showed positive immunoreactivity for activated GSK-3 beta in 44% of the samples, whereas membranous beta-catenin and nuclear beta-catenin were observed in 19% and 20% of the samples, respectively. However, GSK-3 beta activation was not correlated with the expression of either membranous beta-catenin or nuclear beta-catenin. Moreover, SNU gastric cancer cell lines over-expressing kinase dead GSK-3 beta and the same cells treated with a GSK-3 beta inhibitor showed that GSK-3 beta inhibition did not alter either the protein expression or transcriptional activity of beta-catenin. In addition, GSK-3 beta activation was positively correlated with the expressions of anti-adenomatous polyposis coli (p = 0.002), p16 (p < 0.001), p21 (p < 0.001), p27 (p = 0.001), and p53 (p = 0.013). On the other hand, the nuclear expression of beta-catenin was positively correlated with those of Bcl-2 (p = 0.025) and cyclin D1 (p = 0.043), but these expressions were not correlated with GSK-3 beta activation. Thus, the GSK-3 beta pathway seems to function in gastric cancer cells without involving the beta-catenin pathway. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | GSK-3β | ko_KR |
dc.subject | immunohistochemistry | ko_KR |
dc.subject | tissue microarray | ko_KR |
dc.subject | gastric carcinoma | ko_KR |
dc.subject | β-catenin | ko_KR |
dc.title | Glycogen synthase kinase-3β does not correlate with the expression and activity of β-catenin in gastric cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조유진 | - |
dc.contributor.AlternativeAuthor | 윤지연 | - |
dc.contributor.AlternativeAuthor | 고영산 | - |
dc.contributor.AlternativeAuthor | 김수연 | - |
dc.contributor.AlternativeAuthor | 조성진 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 박종완 | - |
dc.contributor.AlternativeAuthor | 연홍덕 | - |
dc.contributor.AlternativeAuthor | 김지훈 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.identifier.doi | 10.1111/j.1600-0463.2010.02659.x | - |
dc.citation.journaltitle | APMIS | - |
dc.description.citedreference | Jiang H, 2009, SCAND J GASTROENTERO, V44, P1452, DOI 10.3109/00365520903342166 | - |
dc.description.citedreference | Wang Q, 2008, CELL DEATH DIFFER, V15, P908, DOI 10.1038/cdd.2008.2 | - |
dc.description.citedreference | Lee BL, 2008, CARCINOGENESIS, V29, P44, DOI 10.1093/carcin/bgm232 | - |
dc.description.citedreference | Shakoori A, 2007, CANCER SCI, V98, P1388, DOI 10.1111/j.1349-7006.2007.00545.x | - |
dc.description.citedreference | Ma C, 2007, CANCER RES, V67, P7756, DOI 10.1158/0008-5472.CAN-06-4665 | - |
dc.description.citedreference | Forde JE, 2007, CELL MOL LIFE SCI, V64, P1930, DOI 10.1007/s00018-007-7045-7 | - |
dc.description.citedreference | Li YW, 2007, J BIOL CHEM, V282, P21542, DOI 10.1074/jbc.M701978200 | - |
dc.description.citedreference | Kunnimalaiyaan M, 2007, MOL CANCER THER, V6, P1151, DOI 10.1158/1535-7163.MCT-06-0665 | - |
dc.description.citedreference | Jemal A, 2007, CA-CANCER J CLIN, V57, P43 | - |
dc.description.citedreference | Soto-Cerrato V, 2007, MOL CANCER THER, V6, P362, DOI 10.1158/1535-7163.MCT-06-0266 | - |
dc.description.citedreference | Cao Q, 2006, CELL RES, V16, P671, DOI 10.1038/sj.cr.7310078 | - |
dc.description.citedreference | Crew KD, 2006, WORLD J GASTROENTERO, V12, P354 | - |
dc.description.citedreference | Tan J, 2005, CANCER RES, V65, P9012, DOI 10.1158/0008-5472.CAN-05-1226 | - |
dc.description.citedreference | Lee JH, 2005, BIOCHEM BIOPH RES CO, V335, P771, DOI 10.1016/j.bbrc.2005.07.146 | - |
dc.description.citedreference | Shakoori A, 2005, BIOCHEM BIOPH RES CO, V334, P1365, DOI 10.1016/j.bbrc.2005.07.041 | - |
dc.description.citedreference | Farago M, 2005, CANCER RES, V65, P5792 | - |
dc.description.citedreference | Ghosh JC, 2005, CLIN CANCER RES, V11, P4580 | - |
dc.description.citedreference | Al-Aynati MM, 2004, CLIN CANCER RES, V10, P1235 | - |
dc.description.citedreference | Liao XB, 2003, MOL CANCER THER, V2, P1215 | - |
dc.description.citedreference | Lee HS, 2003, J PATHOL, V200, P39, DOI 10.1002/path.1288 | - |
dc.description.citedreference | Doble BW, 2003, J CELL SCI, V116, P1175, DOI 10.1242/jcs.00384 | - |
dc.description.citedreference | Manoukian AS, 2002, ADV CANCER RES, V84, P203 | - |
dc.description.citedreference | Woo DK, 2001, INT J CANCER, V95, P108 | - |
dc.description.citedreference | Lee HS, 2001, INT J CANCER, V91, P619 | - |
dc.description.citedreference | Sun WJ, 2001, DRUGS, V61, P1545 | - |
dc.description.citedreference | Polakis P, 2000, GENE DEV, V14, P1837 | - |
dc.description.citedreference | Kikuchi A, 2000, BIOCHEM BIOPH RES CO, V268, P243 | - |
dc.description.citedreference | Aberle H, 1997, EMBO J, V16, P3797 | - |
dc.description.citedreference | Morin PJ, 1997, SCIENCE, V275, P1787 | - |
dc.description.citedreference | WOODGETT JR, 1984, BIOCHIM BIOPHYS ACTA, V788, P339 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.