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Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Joo Hyun | - |
dc.contributor.author | Lee, Byung-Lan | - |
dc.contributor.author | Yoon, Jiyeon | - |
dc.contributor.author | Kim, Jin | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Kim, Min A. | - |
dc.date.accessioned | 2012-07-10T04:33:35Z | - |
dc.date.available | 2012-07-10T04:33:35Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | HUMAN PATHOLOGY; Vol.41(12); 1664-1673 | ko_KR |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78696 | - |
dc.description.abstract | Focal adhesion kinase, a nonreceptor tyrosine kinase, is known to be associated with tumor progression in various tumors Because the clinical implications of focal adhesion kinase overexpression in gastric cancer have been inconsistent, we extended previous studies and evaluated focal adhesion kinase gene amplification as well as its protein expression Immunohistochemical tissue array analysis showed that focal adhesion kinase immunoreactivity was present in both the cytoplasm and membrane of gastric cancer cells Diffuse immunoreactivity of focal adhesion kinase protein in cytoplasm or membrane was found in 240 (54%) or 263 (59%) of 444 surgical samples, respectively, and positively correlated with tumor size, depth of tumor infiltration, nodal metastasis, distant metastasis, lymphatic invasion, and venous invasion (P < 001) Regarding focal adhesion kinase gene amplification, fluorescence in situ hybridization analysis showed focal adhesion kinase gene amplification in 34 (8 9%) of 384 gastric cancer specimens, whereas there was no amplification in any case of atrophy, intestinal metaplasia, or adenoma/dysplasia Focal adhesion kinase gene amplification was positively associated with age (P = 012), tumor size (P = 007), nodal metastasis (P = 021), distant metastasis (P = 029), lymphatic invasion (P = 006), venous invasion (P = 032), and perineural invasion (P = 023) Focal adhesion kinase protein expression and gene amplification were positively correlated with each other, and each of them was found to be an Independent poor prognostic factor (P < 01) In conclusion, our results showed that either focal adhesion kinase protein expression or focal adhesion kinase gene amplification was significantly correlated with cancer progression and poor prognosis in gastric cancer Thus, focal adhesion kinase gene amplification could supplement its protein expression for the diagnosis and treatment of gastric cancer. | ko_KR |
dc.description.sponsorship | Supported by grant 03-2010-0030 from the SNUH Research Fund. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | ko_KR |
dc.subject | Stomach neoplasm | ko_KR |
dc.subject | In situ hybridization | ko_KR |
dc.subject | PTK2 protein | ko_KR |
dc.subject | Gene expression | ko_KR |
dc.subject | Prognosis | ko_KR |
dc.title | Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박주현 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.contributor.AlternativeAuthor | 윤지연 | - |
dc.contributor.AlternativeAuthor | 김진 | - |
dc.contributor.AlternativeAuthor | 김민아 | - |
dc.contributor.AlternativeAuthor | 양한광 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.identifier.doi | 10.1016/j.humpath.2010.06.004 | - |
dc.citation.journaltitle | HUMAN PATHOLOGY | - |
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dc.description.tc | 1 | - |
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