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Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-rasLA1 mice

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Authors
Jin, H; Xu, C-X; Kim, H-W; Chung, Y-S; Shin, J-Y; Chang, S-H; Park, S-J; Lee, E-S; Hwang, S-K; Kwon, J-T; Minai-Tehrani, A; Woo, M; Noh, M-S; Youn, Hee Jeong; Kim, Dae-Yong; Yoon, Byung-Il; Lee, K-H; Kim, T-H; Cho, C-S; Cho, Myung-Haing
Issue Date
2008-02-22
Publisher
Nature Publishing Group
Citation
Cancer Gene Ther 2008; 15: 275-283
Keywords
urocanic acid-modified chitosanPTENaerosol gene deliverylung cancer
Abstract
The low efficiency of conventional therapies in achieving long-term survival of lung cancer patients calls for development of novel
options. Revisiting of aerosol gene delivery may provide an alternative for safe and effective treatment for lung cancer. In this study,
imidazole ring-containing urocanic acid-modified chitosan (UAC) designed in the previous study was used as a gene carrier. The
potential effects of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) on Akt-related signals and cell cycle
regulation were evaluated. Aerosols of UAC–PTEN were delivered into K-rasLA1 lung cancer model mice through the nose-only
inhalation system twice a week for total 4 weeks. Delivered PTEN suppressed lung tumor development significantly through nuclear
complex formation between PTEN and p53, suppressing Akt-related signals as well as cell cycle regulation. Together, our results
suggest that aerosol delivery of UAC–PTEN may be compatible with noninvasive in vivo gene therapy.
ISSN
0929-1903
Language
English
URI
http://hdl.handle.net/10371/7888
DOI
https://doi.org/10.1038/sj.cgt.7701116
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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