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Surface modification of polydimethylsiloxane (PDMS) induced proliferation and neural-like cells differentiation of umbilical cord blood-derived mesenchymal stem cells

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Authors
Kim, Sun-Jung; Lee, Jae Kyoo; Kim, Jin Won; Jung, Ji-Won; Seo, Kwangwon; Park, Sang-Bum; Roh, Kyung-Hwan; Lee, Sae-Rom; Hong, Yun Hwa; Kim, Sang Jeong; Lee, Yong-Soon; Kim, Sung June; Kang, Kyung-Sun
Issue Date
2008-08
Publisher
Springer Verlag
Citation
J. Mater. Sci. Mater. Med. 19 (2008) 2953
Abstract
Stem cell-based therapy has recently emerged
for use in novel therapeutics for incurable diseases. For
successful recovery from neurologic diseases, the most
pivotal factor is differentiation and directed neuronal cell
growth. In this study, we fabricated three different widths of
a micro-pattern on polydimethylsiloxane (PDMS; 1, 2, and
4 lm). Surface modification of the PDMS was investigated
for its capacity to manage proliferation and differentiation
of neural-like cells from umbilical cord blood-derived
mesenchymal stem cells (UCB-MSCs). Among the micropatterned
PDMS fabrications, the 1 lm-patterned PDMS
significantly increased cell proliferation and most of the cells
differentiated into neuronal cells. In addition, the 1 lmpatterned
PDMS induced an increase in cytosolic calcium,
while the differentiated cells on the flat and 4 lm-patterned
PDMS had no response. PDMS with a 1 lmpattern was also
aligned to direct orientation within 10 angles. Taken together,
micro-patterned PDMS supported UCB-MSC
proliferation and induced neural like-cell differentiation.
Our data suggest that micro-patterned PDMS might be a
guiding method for stem cell therapy that would improve its
therapeutic action in neurological diseases
ISSN
0957-4530 (print)
1573-4838 (online)
Language
English
URI
http://hdl.handle.net/10371/7923
DOI
https://doi.org/10.1007/s10856-008-3413-6
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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