지연성 운동장애의 유병율에 관한 연구

Abstract

The purpose of this study is to determine the prevalence of tardive dyskinesia CTD) in a chronic population. The examinations were carried out independently by the senior author (K) and the second author (C). 110 male puticutsjmcan age 29.58) and l~H female patients (mean age :J0.3G) in ,1 inpatient wards of National Mental Hospital in Seoul were examined for the presence of TD by means of Abnormal Involuntary Movement Scale CAlMS). The reexamination was done from 8 to 11 weeks after first examination. The rcliabilities of the AIMS were assessed by kappa statistic. Interrater reliubiIities and test-retest rcliabilities for male subjects were satisfactory. But those of female subjects were not quite satisfactory. Among the subjects, the patients with a history of antipsychotic medication for less than 3 months and organic conditions including drug or alcohol depend· ence or mental retardation were excluded when the prevalence rate were determined and the results were as follows: 1. When TD was defined those with a rating 3 or higher for anyone or more than one of seven body parts, the prevalence rate was 19. 15% in male and 21. 7496 in female by the examiner K and 18.0996 in male 12.1796 in female by the examiner C'nnd 13.8396 in male and !J.S796 in female by the rat ing of both examiner. 2. When TD was defined as those with a rating 3 or higher for global rating, the prevalence rate was 15. 9696 in male 18.26% in female by the exam incr K, 8.5% in male and 10.1396 in female by the examiner C'and 8. Gl% in male and 7.8396 in female by both examiner. Among dyskinetic population, moderate dyskinesia involved extremities were seen most frequently. There was no significant relationship between the occurrence of TD and the duration of antipsychotics treatment. And there was also no significant relationship between the severity of global rating and age' and the amount of antipsychotic medication on the day of the examination in schizophrenic patients. However, a significant relationship was found between the global rating and duration of antipsychotics treatment in male schizophrenic patients. That is significantly higher proportion of male patients (p< 0.01) with global rating 100 higher compared to those with global rating 0 had a history of antipsychotic med ication for more than two years.