이산화질소-아황산 혼합가스흡입이 백서 각장기의 장기-체중비, 수분함량 및 혈액상의 병화에 미치는 영향
The Effects of Acute Exposure to NO2-SO2 Mixed Gas on the Organ-Body Weight Ratio, Organ Water Content and Hemogram

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서울대학교 의과대학
Seoul J Med 1982;23(1):114-120
Nitrogen dioxide (NO,) and sulfur dioxide (SO,)
are significant components of air pollutants. Their
main source is the automobile exhaust. By difference
of geographical variables and climatological condition,
NO, plays as major component of photochemical
oxidant as in Los Angeles and SO, is responsible in
London type Smog Accident. In prior to these two
irritant gas became serious air pollutants as the cause
of hazard to human body and vegetables, main interest
had been concentrated on the acute poisoning by relatively high concentration in the field of the
industrial hygiene. But in urban life,many people are
apt to inhale various noxious gases, even though the
concentrations are still low to evoke noticeable acute
poisoning. Although we had seen in air pollution
accident, manifest health hazards could be observed.
As the irritant gases, these two gases act on epi thelium
of air way tract and provokes inflammatory
responses, and also the formation of methemoglobin
by nitrogen dioxide has been observed.
There are many case reports on the simple exposure
to these two gases, but very few reports on the
combined effect of these two gases. In air pollution,
many toxic gases are existing in mixed state. The
additive. synergistic or antagonistic actions are expected
by the type of combination.
Authors designed tbis study to evaluate the effects
of NO,-SO, mixed gas inhalation on the organ-body
weight ratio, water contents and hemogram of rat.
The rats were exposed mixed gas of 50ppm NO. and
50ppm SO, for 4 hours, following findings were
1. In experimental group, organ-body weight ratioincreased
in the lung and the brain significantly.
Increase rate was predominant in the right middle
and right lower lobe. The water contents showed
same tendency.
2. The formation of methemoglobin increased in
the experimental group compared to the control group
and also there was significant increase in the number
of reticulocyte.
3. The decrease of mean corpuscular volume was
accompanied by the increase in mean corpuscular
hemoglobin concentration.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.1 (1982)
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