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Transmembrane 4 L Six Family Member 5 (TM4SF5) Enhances Migration and Invasion of Hepatocytes for Effective Metastasis

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dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorKim, Tae You-
dc.contributor.authorKwak, Tae Kyoung-
dc.contributor.authorKim, Hyeonjung-
dc.contributor.authorLee, Hyo Jeong-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorCho, Moonjae-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorKim, Semi-
dc.date.accessioned2013-01-14T06:15:16Z-
dc.date.available2013-01-14T06:15:16Z-
dc.date.issued2010-09-01-
dc.identifier.citationJOURNAL OF CELLULAR BIOCHEMISTRY; Vol.111, No.1, pp.59-66ko_KR
dc.identifier.issn0730-2312-
dc.identifier.urihttp://hdl.handle.net/10371/80399-
dc.description.abstractOverexpression of transmembrane 4 L SIX family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion. and tumor metastasis remain unknown Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined We found that TM4SF5 expression facilitated migration, invadopodia formation. MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects Altogether, TM4SF5-mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers J. Cell. Biochem. 111: 59-66, 2010 (C) 2010 Wiley-Liss. Incko_KR
dc.language.isoenko_KR
dc.publisherWILEY-LISSko_KR
dc.subjectINVADOPODIAko_KR
dc.subjectMIGRATIONko_KR
dc.subjectMMPko_KR
dc.subjectTm4SF5ko_KR
dc.subjectINVASIONko_KR
dc.subjectMETASTASISko_KR
dc.titleTransmembrane 4 L Six Family Member 5 (TM4SF5) Enhances Migration and Invasion of Hepatocytes for Effective Metastasisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor김태유-
dc.contributor.AlternativeAuthor곽태경-
dc.contributor.AlternativeAuthor김현중-
dc.contributor.AlternativeAuthor이효정-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor조문제-
dc.contributor.AlternativeAuthor이정원-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor김세미-
dc.identifier.doi10.1002/jcb.22662-
dc.citation.journaltitleJOURNAL OF CELLULAR BIOCHEMISTRY-
dc.description.tc5-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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