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Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jang Ho | - |
dc.contributor.author | Bae, Joon-Ho | - |
dc.contributor.author | Lim, Ki Taek | - |
dc.contributor.author | Choi, Seong Jun | - |
dc.contributor.author | Im, Ae Lee | - |
dc.contributor.author | Park, Jung-Sub | - |
dc.contributor.author | Choung, Pill-Hoon | - |
dc.contributor.author | Lee, Eung Tae | - |
dc.contributor.author | Chung, Jong Hoon | - |
dc.contributor.author | Choung, Yun-Hoon | - |
dc.date.accessioned | 2013-01-14T07:51:59Z | - |
dc.date.available | 2013-01-14T07:51:59Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.90A, No.2, pp.446-455 | ko_KR |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80493 | - |
dc.description.abstract | Perforated tympanic membranes (TM) and otitis media can be managed with a paper patch or tympanoplasty. However, a paper patch is not biocompatible and tympanoplasty requires complex aseptic surgical procedures. A novel biocompatible patch with a water-insoluble chitosan as the main component was prepared. Optimal mechanical characteristics of a water-insoluble chitosan patch scaffold (CPS) was similar to 40 mu m in thickness, 7 MPa in tensile strength, and 107% in percent elongation, even though the characteristics varied significantly depending on the concentrations of chitosan and glycerol. SEM of the CPSs showed a very smooth surface as compared with that of the paper patches. These CPSs showed no cytotoxicity and had a stimulating effect on the proliferation of TM cells in in vitro study. In in vivo study, 4 (21.19%) and 1.7 (89.5%) TMs out of 19 adult rats with CPSs showed no perforations at 1 and 2 weeks, respectively. However, left control TMs showed healing of 0 (0%) at 1 week and 18 (94.7%) at 2 weeks. TEM findings of regenerated eardrums using CPSs showed thinner, smoother, and more compact tissues than spontaneously healed eardrums. A CPS was more effective than spontaneous healing to repair traumatic TM perforations. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 446-455,2009 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Wiley-Blackwell | ko_KR |
dc.subject | tympanic membrane | ko_KR |
dc.subject | perforation | ko_KR |
dc.subject | otitis media | ko_KR |
dc.subject | chitosan patch scaffold | ko_KR |
dc.subject | healing | ko_KR |
dc.title | Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김장호 | - |
dc.contributor.AlternativeAuthor | 배준호 | - |
dc.contributor.AlternativeAuthor | 임기택 | - |
dc.contributor.AlternativeAuthor | 최성준 | - |
dc.contributor.AlternativeAuthor | 임애리 | - |
dc.contributor.AlternativeAuthor | 박정섭 | - |
dc.contributor.AlternativeAuthor | 정필훈 | - |
dc.contributor.AlternativeAuthor | 이응태 | - |
dc.contributor.AlternativeAuthor | 정종훈 | - |
dc.contributor.AlternativeAuthor | 정연훈 | - |
dc.identifier.doi | 10.1002/jbm.a.32119 | - |
dc.citation.journaltitle | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.description.tc | 6 | - |
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