S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing
- Min, Seung-Ki; Lee, Sang-Chul; Hong, Seong-Doo; Chung, Chong-Pyoung; Min, Byung-Moo; Park, Won Ho
- Issue Date
- Biomaterials; Vol.31, No.17, pp.4725-4730
- Laminin-5-derived peptide; Wound healing; Wound dressing material; Re-epithelialization; Tissue-engineering
- Considerable effort has been directed towards regenerating defective tissues using tissue-engineering methods. Recently, peptides have been recognized as a valuable scientific tool in the field of tissue-engineering. The PPFLMLLKGSTR motif of the human laminin-5 alpha3 chain has been previously reported to promote keratinocyte survival; however, the in vivo effects of the PPFLMLLKGSTR motif have not yet been studied. These studies raised the hypothesis that a laminin-5-derived peptide can promote wound healing by accelerating re-epithelialization in vivo. To examine this hypothesis, we applied chitin microfibrous matrices coated with the PPFLMLLKGSTR motif in both rat and rabbit full-thickness cutaneous wound models. Compared with vehicle-treated and peptide-treated cutaneous wounds, the application significantly promoted early-stage wound healing by accelerating re-epithelialization, notably reduced inflammatory cell infiltration, and prominently enhanced fibroblast proliferation. These findings support our hypothesis that the PPFLMLLKGSTR motif acts as a very effective wound healing accelerator by enhancing re-epithelialization. ⓒ 2010 Elsevier Ltd.
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