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The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing

Cited 35 time in Web of Science Cited 31 time in Scopus
Authors
Min, Seung-Ki; Lee, Sang-Chul; Hong, Seong-Doo; Chung, Chong-Pyoung; Min, Byung-Moo; Park, Won Ho
Issue Date
2010
Publisher
Elsevier
Citation
Biomaterials; Vol.31, No.17, pp.4725-4730
Keywords
Laminin-5-derived peptideWound healingWound dressing materialRe-epithelializationTissue-engineering
Abstract
Considerable effort has been directed towards regenerating defective tissues using tissue-engineering methods. Recently, peptides have been recognized as a valuable scientific tool in the field of tissue-engineering. The PPFLMLLKGSTR motif of the human laminin-5 alpha3 chain has been previously reported to promote keratinocyte survival; however, the in vivo effects of the PPFLMLLKGSTR motif have not yet been studied. These studies raised the hypothesis that a laminin-5-derived peptide can promote wound healing by accelerating re-epithelialization in vivo. To examine this hypothesis, we applied chitin microfibrous matrices coated with the PPFLMLLKGSTR motif in both rat and rabbit full-thickness cutaneous wound models. Compared with vehicle-treated and peptide-treated cutaneous wounds, the application significantly promoted early-stage wound healing by accelerating re-epithelialization, notably reduced inflammatory cell infiltration, and prominently enhanced fibroblast proliferation. These findings support our hypothesis that the PPFLMLLKGSTR motif acts as a very effective wound healing accelerator by enhancing re-epithelialization. ⓒ 2010 Elsevier Ltd.
ISSN
0142-9612
Language
English
URI
http://hdl.handle.net/10371/80831
DOI
https://doi.org/10.1016/j.biomaterials.2010.02.045
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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