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Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

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Authors
Lee, Ju-A; Ku, Young; Rhyu, In-Chul; Chung, Chong-Pyoung; Park, Yoon-Jeong
Issue Date
2010
Publisher
Korean Academy of Periodontology
Citation
Journal of Periodontal and Implant Science; Vol.40, No.5. pp.211-219
Keywords
FibrinFibronectinsOligopeptides
Abstract
Purpose: Fibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance bone regeneration in rabbit calvarial defects. Methods: Oligopeptides including fibrin-binding sequences of FN repeats were synthesized on the basis of primary and tertiary human plasma FN structures. Peptide coated and uncoated bone minerals were implanted into 10 mm calvarial defects in New Zealand white rabbits, and the animals were sacrificed at 4 or 8 weeks after surgery. After specimens were prepared, histologic examination and histomorphometric analysis were performed. Results: At 4 weeks after surgery, the uncoated groups showed a limited amount of osteoid formation at the periphery of the defect and the oligopeptide coated groups showed more osteoid formation and new bone formation in the center of the defect as well as at the periphery. At 8 weeks, both sites showed increased new bone formation. However, the difference between the two sites had reduced. Conclusions: Fibrin-binding synthetic oligopeptide derived from FN on deproteinized bovine bone enhanced new bone formation in rabbit calvarial defects at the early healing stage. This result suggests that these oligopeptides can be beneficial in reconstructing oral and maxillofacial deformities or in regenerating osseous bone defects. ⓒ 2010 Korean Academy of Periodontology.
ISSN
2093-2278
Language
English
URI
http://hdl.handle.net/10371/80867
DOI
https://doi.org/10.5051/jpis.2010.40.5.211
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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