Publications
Detailed Information
Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Young Jin | - |
dc.contributor.author | Choi, Yoon La | - |
dc.contributor.author | Cho, Eun Yoon | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Kim, Jee Soo | - |
dc.contributor.author | Yang, Jung-Hyun | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Kim, Jung Han | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Lee, Sang Jin | - |
dc.contributor.author | Hwang, Yu Kyeong | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.date.accessioned | 2013-01-23T02:29:29Z | - |
dc.date.available | 2013-01-23T02:29:29Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | BREAST CANCER RESEARCH AND TREATMENT, Vol.113, No.1, pp.83-93 | ko_KR |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81017 | - |
dc.description.abstract | Purpose Abnormal expression of the cell cycle regulatory protein Bmi-1 has been studied in breast cancer, but the clinical relevance has not been fully elucidated. We studied the expression of Bmi-1 protein in breast cancer patients to define its clinical significance in breast cancer. Experimental Design Tissue microarrays were performed to evaluate the expression of Bmi-1 by immunohistochemistry in tumor tissues from 960 patients with stage I-III breast cancer. We assessed the relationship between the expression of Bmi-1 and pathologic prognostic indices as well as clinical long-term follow up outcome. Results Bmi-1 was expressed in 53.2% of breast cancer patients by immunohistochemistry, and the expression of Bmi-1 was significantly correlated with favorable prognostic indices at diagnosis. In univariate analysis, patients with Bmi-1 expression showed favorable relapse-free survival (88.6 +/- A 2.7% vs. 72.3 +/- A 4.3%, P = 0.041) and favorable overall survival (93.5 +/- A 2.2% vs. 82.6 +/- A 3.5%, P < 0.001) than patients without Bmi-1 expression. According to multivariate analyses, Bmi-1 expression was identified as independent prognostic factor for overall survival with a statistical significance (hazard ratio of Bmi-1 (-) patients compared to Bmi-1 (+) patients, 1.744; 95% CI, 1.013-3.003; P = 0.045). This correlation of Bmi-1 expression with favorable overall survival was maintained in patients underwent uniform chemotherapy, regardless of undergoing adjuvant chemotherapy. In a subset analysis according to ER status, Bmi-1 expression associated with favorable overall survival only in ER-positive patients. Conclusions Bmi-1 expression assessed with Immunohistochemistry may be associated with favorable overall survival in breast cancer patients, especially in patients with ER-positive breast cancer. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Springer Verlag | ko_KR |
dc.subject | Bmi-1 | ko_KR |
dc.subject | Prognostic markers | ko_KR |
dc.subject | Immunohistochemistry | ko_KR |
dc.subject | Breast cancer | ko_KR |
dc.subject | Cell cycle regulator | ko_KR |
dc.title | Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최영진 | - |
dc.contributor.AlternativeAuthor | 최윤라 | - |
dc.contributor.AlternativeAuthor | 조은윤 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 공구 | - |
dc.contributor.AlternativeAuthor | 김지수 | - |
dc.contributor.AlternativeAuthor | 양정현 | - |
dc.contributor.AlternativeAuthor | 남석진 | - |
dc.contributor.AlternativeAuthor | 김정한 | - |
dc.contributor.AlternativeAuthor | 이정언 | - |
dc.contributor.AlternativeAuthor | 이상진 | - |
dc.contributor.AlternativeAuthor | 황유경 | - |
dc.contributor.AlternativeAuthor | 성기웅 | - |
dc.identifier.doi | 10.1007/s10549-008-9909-4 | - |
dc.citation.journaltitle | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.description.tc | 17 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.