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Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Ingie | - |
dc.contributor.author | Kim, Jihye | - |
dc.contributor.author | Lee, Junuk | - |
dc.contributor.author | Park, Sungmo | - |
dc.contributor.author | Kim, Jeongyeon | - |
dc.contributor.author | Park, Kyungjoon | - |
dc.contributor.author | Lee, Sukwon | - |
dc.contributor.author | Park, Sang-Hyun | - |
dc.contributor.author | Lee, Seungbok | - |
dc.contributor.author | Choi, Sukwoo | - |
dc.contributor.author | Eom, Khee Dong | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Lee, Hyun Woo | - |
dc.contributor.author | An, Bobae | - |
dc.contributor.author | Song, Beomjong | - |
dc.date.accessioned | 2013-01-23T05:23:49Z | - |
dc.date.available | 2013-01-23T05:23:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | PLoS ONE; Vol.6, No.9, pp,e24260 | ko_KR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81030 | - |
dc.description.abstract | It is generally believed that after memory consolidation, memory-encoding synaptic circuits are persistently modified and become less plastic. This, however, may hinder the remaining capacity of information storage in a given neural circuit. Here we consider the hypothesis that memory-encoding synaptic circuits still retain reversible plasticity even after memory consolidation. To test this, we employed a protocol of auditory fear conditioning which recruited the vast majority of the thalamic input synaptic circuit to the lateral amygdala (T-LA synaptic circuit; a storage site for fear memory) with fear conditioning-induced synaptic plasticity. Subsequently the fear memory-encoding synaptic circuits were challenged with fear extinction and re-conditioning to determine whether these circuits exhibit reversible plasticity. We found that fear memory-encoding T-LA synaptic circuit exhibited dynamic efficacy changes in tight correlation with fear memory strength even after fear memory consolidation. Initial conditioning or re-conditioning brought T-LA synaptic circuit near the ceiling of their modification range (occluding LTP and enhancing depotentiation in brain slices prepared from conditioned or re-conditioned rats), while extinction reversed this change (reinstating LTP and occluding depotentiation in brain slices prepared from extinguished rats). Consistently, fear conditioning-induced synaptic potentiation at T-LA synapses was functionally reversed by extinction and reinstated by subsequent re-conditioning. These results suggest reversible plasticity of fear memory-encoding circuits even after fear memory consolidation. This reversible plasticity of memory-encoding synapses may be involved in updating the contents of original memory even after memory consolidation. ⓒ 2011 Hong et al. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Public Library of Science | ko_KR |
dc.title | Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍인기 | - |
dc.contributor.AlternativeAuthor | 김지혜 | - |
dc.contributor.AlternativeAuthor | 이준욱 | - |
dc.contributor.AlternativeAuthor | 박성모 | - |
dc.contributor.AlternativeAuthor | 김정연 | - |
dc.contributor.AlternativeAuthor | 박경준 | - |
dc.contributor.AlternativeAuthor | 이석원 | - |
dc.contributor.AlternativeAuthor | 박상현 | - |
dc.contributor.AlternativeAuthor | 이승복 | - |
dc.contributor.AlternativeAuthor | 최석우 | - |
dc.contributor.AlternativeAuthor | 엄기동 | - |
dc.contributor.AlternativeAuthor | 김현 | - |
dc.contributor.AlternativeAuthor | 이현우 | - |
dc.contributor.AlternativeAuthor | 안보배 | - |
dc.contributor.AlternativeAuthor | 송범종 | - |
dc.identifier.doi | 10.1371/journal.pone.0024260 | - |
dc.citation.journaltitle | PLoS ONE | - |
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