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Influences of hyaluronic acid on the anticandidal activities of lysozyme and the peroxidase system

Cited 21 time in Web of Science Cited 19 time in Scopus
Authors
Kang, J.-H.; Kim, Y.-Y.; Chang, J.-Y.; Kho, Hong-Seop
Issue Date
2011
Publisher
John Wiley & Sons
Citation
Oral Diseases; Vol.17, No.6, pp.577-583
Keywords
Anticandidal activityHyaluronic acidPeroxidaseLysozyme
Abstract
Objective: To investigate the fungistatic and fungicidal activity of hyaluronic acid (HA) and the influences of HA on the anticandidal activities of lysozyme and the peroxidase system. Materials and Methods: HA, hen egg-white lysozyme, and the bovine lactoperoxidase system were used. Candida albicans ATCC 10231, 18804, and 11006 strains were used in the experiments. The fungistatic activity of HA was determined by measuring the optical densities of the cultures. The candidacidal activity of HA and the influences of HA on the candidacidal activities of lysozyme and the peroxidase system were determined by comparing the numbers of colony-forming units. Results: Hyaluronic acid displayed inhibitory effects on the growth of C. albicans, and the inhibitory effects were proportional to HA concentration. HA did not have any measurable candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme, and the peroxidase system that was proportional to HA concentration. HA at 1.0-2.0mgml -1 almost completely inhibited the candidacidal activities of lysozyme and the peroxidase system. Conclusions: Hyaluronic acid possesses fungistatic activity but no candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme and the peroxidase system. ⓒ 2011 John Wiley & Sons A/S.
ISSN
1601-0825
Language
English
URI
http://hdl.handle.net/10371/81060
DOI
https://doi.org/10.1111/j.1601-0825.2011.01807.x
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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