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Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Chan | - |
dc.contributor.author | Yang, Hyun-Sik | - |
dc.contributor.author | Jeon, Inpyo | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Park, Sang Min | - |
dc.creator | 박상민 | - |
dc.date.accessioned | 2013-04-09T08:05:06Z | - |
dc.date.available | 2013-04-09T08:05:06Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | CANADIAN MEDICAL ASSOCIATION JOURNAL Vol.183 No.14, pp. 1073-1084 | - |
dc.identifier.issn | 0820-3946 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81823 | - |
dc.description.abstract | Background: Epidemiologic studies have reported inconsistent findings regarding the association between the use of angiotensin-converting-enzyme (ACE) inhibitors or angio tensin-receptor blockers and the risk of cancer. We performed a meta-analysis of observational studies to assess the association.Methods: We searched MEDLINE, EMBASE and the Cochrane Library to identify studies through January 2011. Two evaluators independently reviewed and selected articles of cohort and case-control studies on the basis of predetermined selection criteria.Results: Of 3970 screened articles, 12 cohort studies and 16 case-control studies were selected for analysis. We found no significant association between the use of ACE inhibitors or angiotensin-receptor blockers and the overall risk of cancer (relative risk [RR] 0.96, 95% confidence interval [CI] 0.90-1.03). We found a decreased risk of cancer associated with use of either medication when we restricted the analyses to cohort and nested case-control studies (RR 0.90, 95% CI 0.83-0.97) or to studies with long-term follow-up of more than five years (RR 0.89, 95% CI 0.83-0.96). In the subgroup meta-analyses by cancer site, a decreased risk was identified for esophageal cancer, whereas an increased risk was found for melanoma and kidney cancer.Interpretation: No significant association was found between the use of ACE inhibitors or angiotensin-receptor blockers and overall risk of cancer. A possible beneficial effect associated with use of either medication was suggested in sensitivity analyses, including those of studies with long-term follow-up. Large randomized controlled trials with long-term follow-up are needed to specifically test the effect of each of these medications on the risk of cancer. | en |
dc.language.iso | en | en |
dc.publisher | Canadian Medical Association | en |
dc.subject | 복합학 | en |
dc.title | Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 윤찬 | - |
dc.contributor.AlternativeAuthor | 양현식 | - |
dc.contributor.AlternativeAuthor | 전인표 | - |
dc.contributor.AlternativeAuthor | 장유수 | - |
dc.contributor.AlternativeAuthor | 박상민 | - |
dc.identifier.doi | 10.1503
/cmaj.101497 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000052039/6 | - |
dc.description.srnd | SEQ:6 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000052039 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077862 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:8.217 | - |
dc.description.srnd | FILENAME:46_Use of angiotensin-converting-enzyme inhibitors or.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:smpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:N | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000052039/6 | - |
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