Browse

Meta-analysis: selective serotonin reuptake inhibitors and colon cancer

Cited 14 time in Web of Science Cited 15 time in Scopus
Authors
Lee, Hyun-Ki; Eom, Chun-Sick; Kwon, Young Min; Ahn, Jeong Soo; Kim, Sarah; Park, Sang Min
Issue Date
2012-10
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY Vol.24 No.10, pp. 1153-1157
Keywords
복합학antidepressantcolon cancercolorectal cancermeta-analysisselective serotonin reuptake inhibitors
Abstract
Objective To perform meta-analyses using observational studies to assess the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of colorectal cancer.Methods A systematic search of relevant studies published through February 2012 was carried out using the Medline (PubMed), Embase, and Cochrane Library databases. We reviewed the observational studies that were associated with our subject and carried out a meta-analysis.Results Out of 324 screened articles, six observational studies were included in the final analyses. According to this meta-analysis, the use of SSRIs was not associated with an increased risk of colorectal cancer in pooled analyses (adjusted odds ratio 0.89, 95% confidence interval 0.79-1.01). This finding was consistently observed in subgroup analyses of study area, location of colorectal cancer, duration of SSRI use, study quality, adjustment for NSAID use, and the prevalence of overweight.Conclusion Our research shows that the use of SSRIs does not increase the risk of colorectal cancer. Further studies are needed to confirm the association between SSRIs and colorectal cancer. Eur J Gastroenterol Hepatol 24:1153-1157 (C) 2012 Wolters Kluwer Health | Lippincott Williams Wilkins.
ISSN
0954-691X
Language
English
URI
http://hdl.handle.net/10371/81831
DOI
https://doi.org/10.1097/MEG.0b013e328355e289
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse