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Modulation of signaling between TM4SF5 and integrins in tumor microenvironment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sin-Ae | - |
dc.contributor.author | Park, Ki Hun | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.creator | 이정원 | - |
dc.date.accessioned | 2013-04-16T07:54:04Z | - |
dc.date.available | 2013-04-16T07:54:04Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | FRONTIERS IN BIOSCIENCE-LANDMARK Vol.16 No.5, pp. 1752-1758 | - |
dc.identifier.issn | 1093-9946 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82066 | - |
dc.description.abstract | TM4SF5 is a transmembrane glycoprotein of the
transmembrane 4 L six family, a branch of the tetraspanin family and highly expressed in many types of cancers. TM4SF5 induces epithelial-mesenchymal transition (EMT) by morphological changes resulting from inactivation of RhoA mediated by stabilized cytosolic p27kip1. TM4SF5- mediated EMT can lead to loss of contact inhibition and enhanced migration/invasion, presumably depending on cross-talks between TM4SF5 and integrins. An anti- TM4SF5 agent appears to target the second extracellular domain of TM4SF5, which is important for cross-talk with integrins, leading to a blockade of TM4SF5-mediated multilayer growth and migration/invasion. In addition, TM4SF5 engages in cross-talk with integrin alpha5 to induce and secrete VEGF, which in turn causes activation of angiogenesis in endothelial cells. Therefore, TM4SF5 plays a central regulatory role in a wide variety of physiological processes through cross-talk with integrins. This review presents current knowledge from in vitro and in vivo observations of the roles of TM4SF5-integrin cooperation in hepatocellular carcinogenesis and discusses important areas for future investigation. | en |
dc.language.iso | en | en |
dc.publisher | FRONTIERS IN BIOSCIENCE INC | en |
dc.subject | 복합학 | en |
dc.subject | Cancer | - |
dc.subject | Epithelial-Mesenchymal Transition | - |
dc.subject | Hepatocarcinoma | - |
dc.subject | Integrin | - |
dc.subject | Microenvironment | - |
dc.subject | TM4SF5 | - |
dc.subject | Review | - |
dc.title | Modulation of signaling between TM4SF5 and integrins in tumor microenvironment | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이신애 | - |
dc.contributor.AlternativeAuthor | 박기훈 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.identifier.doi | 10.2741/3818 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000003910/1 | - |
dc.description.srnd | SEQ:1 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000003910 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A078142 | - |
dc.description.srnd | DEPT_CD:375 | - |
dc.description.srnd | CITE_RATE:4.048 | - |
dc.description.srnd | FILENAME:60JWL_Frontier Bioscience.pdf | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:jwl@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000003910/1 | - |
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