항결핵제투여가 면역형성에미치는 영향에 관한 실험적 연구 - 특히 pyroninophilia 정시세포소견-

Abstract

In the rabbits immunized with hourse serum and ingested with small or large dcses of antituberculous agents (SM., PAS. and INH,) Concurrently, the appearence of pyroninophilic cells in the lyrnphnodes and spleen was studied, and the following results were obtained. 1) The lymphnodes and the spleen of the immunized and concurrently ingested rabbits with small doses of antituberculous drug revealed more pronounced rise in the number of pyroninophilic cells than simply immunized. This changes would be indicated small doses of antituberculous drug ingestion enhancing antibody formation. 2) The spleen and the lymphncdes of immunized and concurrently ingested rabbits with large doses of antituberculous drug showed decrease in the number of pyroninophilic cells than the simply immunized. This changes indicates large doses of antituberculous drug ingestion impair antibody formation conclusively. 3) The spleen and lymphncdes of the rabbits which are immunized and mean while injected with the serum from rabbits which were ingested small doses of .antituberculous drug showed more promoting rising in number of pyroninophilic cells than the simply immunized rabbits. 4) The spleen and lyrnphncdes of the rabbits which were immunized and mean while injected with the serum from rabbits which were ingested large doses of antituberculous drug showed inhibiting decrease in number of pyroninophilic cells than the simply immunized rabbits. 5) According to previous studies it is seen that the serum of small doses ingested antituberculous drug rabbits contain on active producing factor which promotes the appearence of pyroninophilic cells in the spleen and lymphncdes of the immunized rabbits, and that the serum of large doses ingested antitulerculous drug rabbits contain on active producing factor which inhibits the appearenes of the pyroninophilic cells.