동질 임파조직 및 Adjuvant 반복주사백서의 임파결절 병변에 관한 병리조직학적 연구

Abstract

In order to clarify the nature and significance of the so-called autoimmune diseases, the morphologic changes of the lymphnodes of the rats following the repeated injections of the homologous homogenized lymphnodes with or without Freund's adjuvant, were studied. The results were as follows: 1. The mesenteric lymphnodes of the rats received repeated injections of the homologous homogenized lymphnodes and Freund's adjuvant revealed rather marked changes, namely, proliferation of the reticuloendothelial cells in the cortex and medulla, aggregation of histiocytes, collections or infiltration of lymphocytes, large mononuclear cells and plasma cells in intra- or inter-sinusoidal spaces, and thickening of the small blood vessels, while the similar but milder chages were also observed in the lymph nodes of the rats received thehomogenized lymphnodes or adjuvant only. 2. The repeated injections of the homogenized liver were followed not only by the marked infiltration of