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동맥경화증 성인에 관한 연구(제1보) : Studies on Pathogenesis of Atherosclerosis (Report I)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강승호 | - |
dc.contributor.author | 김숭원 | - |
dc.contributor.author | 전성균 | - |
dc.date.accessioned | 2009-08-31T22:28:19Z | - |
dc.date.available | 2009-08-31T22:28:19Z | - |
dc.date.issued | 1961-06-01 | - |
dc.identifier.citation | Seoul J Med, Vol.2 No.1, pp. 59-62 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8243 | - |
dc.description.abstract | There are studies indicating a delayed increase In
the rate of hepatic biosynthesis of fatty acids in whole-body X-irradiated albino rats, as indicated by measurements of acetate-I-C 14 incorporation 1-3). And, in particular, considerable augmentation of cholesterol biosynthesis from acetate in the albino rat liver and adrenals by exposure of the animals to X-irradiation.,5) and also by injection of the detergent Triton WR 13396) have been reported. On the other hand, suppression of the biosynthetic rate was obsevred in animals deprived of food for 24 to 48 hours7. 8) or when fed a cholesterol-enriched diet 9- 13) or when administered 4-cholestenone14•15). Thus, regulation of cholesterol homeostatis in ani· mals by variation in the rate of cholesterol biosynthesis appears to be primarily a function of the liver. It is, therefore, quite natural to expect that radiant energy absorbed in the liver tissue will no doubt cause a significant disturbance with regard to homeostasis of living cells. In addition to X-ray, the author was interested in any alteration of cholesterol biosynthesis caused by administration of ginseng extract, carbon-tetrachloride and ethyl-alcohol to albino rats. Though there are many steps not yet elucidated regarding cholesterol biosynthesis from acetate, it is postulated that three molecules of acetate combine to form branched chain intermediates of six carbon, which, in turn, yield by multiple condensationsqualen. Squalen, in a later stage, is cyclized into lanosterol which is, in turn, transformed into cholesterol. The purpose of the present investigation was to study the variation in the biosynthetic rate of cholesterol in the liver after whole-body Xvirradiauon and ginseng extract, carbon-tetrachloride and ethylalcohol administration to albino rats compared with that in normal rats by measuring the incorporation rate of acetate-LCw into a cell free homogenate of liver. | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 동맥경화증 성인에 관한 연구(제1보) | - |
dc.title.alternative | Studies on Pathogenesis of Atherosclerosis (Report I) | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Kang, Seung Ho | - |
dc.contributor.AlternativeAuthor | Kim, Soong Wun | - |
dc.contributor.AlternativeAuthor | Juhn, Sung Kyun | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 62 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 59-62 | - |
dc.citation.startpage | 59 | - |
dc.citation.volume | 2 | - |
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