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Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies
Cited 16 time in
Web of Science
Cited 16 time in Scopus
- Authors
- Issue Date
- 2012-12
- Publisher
- Elsevier Inc.
- Citation
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol.114 No.6, pp. 785-791
- Keywords
- 의약학
- Abstract
- The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.
- ISSN
- 2212-4403
- Language
- English
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