Perphenazine hydrochloride가 흰쥐 뇌하수체 prolactin에 미치는 영향에 관한 면역조직화학적 연구
Effect of Perphenazine Hydrochloride on the Prolactin Cells of Rat Pituitary Glands

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박철규; 백상호; 박길수
Issue Date
서울대학교 의과대학
Seoul J Med 1973;14(1):61-75
The effect of perphenazine hydrochloride on the
prolactin cells of rat pituitary glands and mammary
glands were studied. Virgin rats which had been
primed with 0.2ml of estradiol for 10 days or not
primed were injected with perphenazine intraperitoneally
for 1 day or repeatedly every 5 days for 15
days. Sections of pituitary glands from them were
carried out to stain the prolactin cells immunohistochemically
using the specific anti-prolactin and antiRGG
labeled with peroxidase. Sections of mammary
glands were stained with hematoxylin and eosin .
Cell counts were made from 10 representative section
of corresponding levels of each gland. and the following
results were obtained.
Even in lower dose of perphenazine. 3mg/day for
1 day. releasing effect of prolactin granules were
apparent. Perphenazine produced a significant
decrease in prolactin cell counts and in the intensities
of staining reaction which were recovered
20 days after injection to almost same levels of
control group.
The higher doses of perphenazine also developed
the proliferation of lobulo-alveolar structure of the
mammary glands. In estradiol-primed rats either
lower or higher doses of perphenazine could revealed
the same findings in both of pituitary and mammary
There were significant increase in adrenal weight
and decrease in ovarian weight.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 14 No.1 (1973)
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