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Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing

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Authors
Kim, Pilnam; Jeong, Hoon Eui; Khademhosseini, Ali; Suh, Kahp Y.
Issue Date
2006-09-14
Publisher
Royal Society of Chemistry
Citation
Lab Chip, 2006, 6, 1432-1437
Keywords
MICROFLUIDIC DEVICE FABRICATIONPHOTOLITHOGRAPHIC POLYMERIZATION CLIPPCAPILLARY-ELECTROPHORESISSURFACE MODIFICATIONSILICON SURFACESSYSTEMSCHANNELSPOLY(DIMETHYLSILOXANE)FLUORESCENCEPROTEINS
Abstract
We present a simple and widely applicable method to fabricate micro- and nanochannels comprised entirely of crosslinked polyethylene glycol ( PEG) by using UV- assisted irreversible sealing to bond partially crosslinked PEG surfaces. The method developed here can be used to form channels as small as similar to 50 nm in diameter without using a sophisticated experimental setup. The manufactured channel is a homogeneous conduit made completely from non-biofouling PEG, exhibits robust sealing with minimal swelling and can be used without additional surface modification chemistries, thus significantly enhancing reliability and durability of microfluidic devices. Furthermore, we demonstrate simple analytical assays using PEG microchannels combined with patterned arrays of supported lipid bilayers ( SLBs) to detect ligand ( biotin) receptor ( streptavidin) interactions.
ISSN
1473-0197
Language
English
URI
http://hdl.handle.net/10371/8375
DOI
https://doi.org/10.1039/b610503c
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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