SHERP

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis

Cited 0 time in webofscience Cited 97 time in scopus
Authors
Maeng, Yong-Sun; Choi, Hyun-Jung; Kwon, Ja-Young; Park, Yong-Won; Choi, Kyu-Sil; Min, Jeong-Ki; Kim, Yun-Hee; Suh, Pann-Ghill; Kang, Kyung-Sun; Won, Moo-Ho; Kim, Young-Myeong; Kwon, Young-Guen
Issue Date
2008-10-02
Publisher
American Society of Hematology
Citation
Blood. 2009;113:233-243
Abstract
Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulin-like growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2+ mobilization induced by the β2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesis-dependent diseases.
ISSN
0006-4971 (print)
1528-0020 (online)
Language
English
URI
http://hdl.handle.net/10371/8609
DOI
https://doi.org/10.1182/blood-2008-06-162891
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse