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A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population

Cited 12 time in Web of Science Cited 10 time in Scopus
Authors
Park, Hansoo; Kim, Hyun-Jin; Lee, Seungbok; Yoo, Yun Joo; Ju, Young Seok; Lee, Jung Eun; Cho, Sung-Il; Sung, Joohon; Kim, Jong-Il; Seo, Jeong-Sun
Issue Date
2013
Publisher
Nature Publishing Group
Citation
Kidney International Vol.83, pp. 285-292
Keywords
복합학family-based association testgenome-wide linkage studyisolated Mongolian populationrenal function
Abstract
The estimated glomerular filtration rate is a well-known measure of renal function and is widely used to follow the course of disease. Although there have been several investigations establishing the genetic background contributing to renal function, Asian populations have rarely been used in these genome-wide studies. Here, we aimed to find candidate genetic determinants of renal function in 1007 individuals from 73 extended families of Mongolian origin. Linkage analysis found two suggestive regions near 9q21 (logarithm of odds (LOD) 2.82) and 15q15 (LOD 2.70). The subsequent family-based association study found 2 and 10 significant single-nucleotide polymorphisms (SNPs) in each region, respectively. The strongest SNPs on chromosome 9 and 15 were rs17400257 and rs1153831 with P-values of 7.21 x 10(-9) and 2.47 x 10(-11), respectively. Genes located near these SNPs are considered candidates for determining renal function and include FRMD3, GATM, and SPATA5L1. Thus, we identified possible loci that determine renal function in an isolated Asian population. Consistent with previous reports, our study found genes linked and associated with renal function in other populations.
ISSN
0085-2538
Language
English
URI
http://hdl.handle.net/10371/91067
DOI
https://doi.org/10.1038/ki.2012.389
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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