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Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seoung-Ae | - |
dc.contributor.author | Kim, Ki-Jeong | - |
dc.contributor.author | Kim, Dong-Won | - |
dc.contributor.author | Kim, Bum-Joon | - |
dc.creator | 김범준 | - |
dc.date.accessioned | 2014-05-01T02:32:21Z | - |
dc.date.available | 2014-05-01T02:32:21Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Journal of Clinical Microbiology, Vol.51 No.12, pp. 3928-3936 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.uri | https://hdl.handle.net/10371/91615 | - |
dc.description.abstract | The issue of hepatitis B virus (HBV) mutations possibly leading to a gender disparity in the progression of liver diseases has not been explored. We aimed to elucidate the relationships of the novel pre-S1 mutations, W4P/R, with the progression of liver diseases and male predominance in a South Korean chronic cohort by use of a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for the detection of the W4P/R mutations and applied it to 292 chronic HBV patients. The pre-S1 mutations from 247 (84.6%) of a total of 292 patients were detected by this assay. W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and liver cirrhosis, 12.4% [19/153] of patients, versus chronic hepatitis and asymptomatic carriage, 1.1% [1/94] of patients) (P<0.001). All of the W4P/R mutants were found in males only. The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C. The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Microbiology | en |
dc.subject | 의약학 | en |
dc.title | Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이승애 | - |
dc.contributor.AlternativeAuthor | 김기정 | - |
dc.contributor.AlternativeAuthor | 김동원 | - |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.identifier.doi | 10.1128/JCM.01505-13 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000006653/6 | - |
dc.description.srnd | SEQ:6 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000006653 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077651 | - |
dc.description.srnd | DEPT_CD:806 | - |
dc.description.srnd | CITE_RATE:4.068 | - |
dc.description.srnd | FILENAME:male-specific w4p_r mutation in the pre-s1.pdf | - |
dc.description.srnd | DEPT_NM:의과학과 | - |
dc.description.srnd | EMAIL:kbumjoon@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2013-01/102/0000006653/6 | - |
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