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Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

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dc.contributor.authorChoe, Ji-Young-
dc.contributor.authorYun, Ji Yun-
dc.contributor.authorJeon, Yoon Kyoung-
dc.contributor.authorKim, Se Hoon-
dc.contributor.authorPark, Gyeongsin-
dc.contributor.authorHuh, Joo Ryoung-
dc.contributor.authorOh, Sohee-
dc.contributor.authorKim, Ji Eun-
dc.date.accessioned2014-05-21T04:59:11Z-
dc.date.available2014-05-21T04:59:11Z-
dc.date.issued2014-05-15-
dc.identifier.citationBMC Cancer, Vol.14 no.1, 335ko_KR
dc.identifier.urihttp://hdl.handle.net/10371/91833-
dc.description.abstractBackground: Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL.
Methods: A total of 121 cases of HL were enrolled to do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers of positive cells using automated image analyzer. Correlations between IDO expression and various cellular infiltrates and clinicopathologic parameters were examined and survival analyses were performed.
Results: IDO was expressed in histiocytes, dendritic cells and some endothelial cells with variable degrees, but not in tumor cells. IDO positive cells were more frequently found in mixed cellularity type than other histologic types, and in cases with EBV+, high Ann Arbor stages, B symptoms, and high IPS (all p < 0.05). High IDO expression was associated with inferior survival (p < 0.001) and reflects an independent prognostic factor in nodular sclerosis HL.
Conclusions: This is the first study suggesting that IDO is the principle immunomodulator and is involved to adverse clinical outcomes of HL.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectHodgkin diseaseko_KR
dc.subjectIndoleamine-pyrrole 2,3-dioxygenaseko_KR
dc.subjectMacrophagesko_KR
dc.subjectStromal cellsko_KR
dc.subjectTumor microenvironmentko_KR
dc.subjectEpstein-barr virus infectionsko_KR
dc.subjectPathologyko_KR
dc.titleIndoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최지영-
dc.contributor.AlternativeAuthor윤지윤-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor김세훈-
dc.contributor.AlternativeAuthor박경신-
dc.contributor.AlternativeAuthor허주령-
dc.contributor.AlternativeAuthor오소희-
dc.contributor.AlternativeAuthor김지은-
dc.identifier.doi10.1186/1471-2407-14-335-
dc.language.rfc3066en-
dc.description.versionPeer Reviewed-
dc.rights.holderJi-Young Choe et al.; licensee BioMed Central Ltd.-
dc.date.updated2014-05-20T07:15:15Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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