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Genetic Influences on Hallux Valgus in Koreans: The Healthy Twin Study

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Chang-Hyung; Lee, Sooji; Kang, HyoJeong; Jung, Da-Eun; Song, Yun-Mi; Lee, Kayoung; Lee, Kyungtai; Hwang, JiHye; Sung, Joohon
Issue Date
2014-03
Publisher
Cambridge University Press
Citation
Twin Research and Human Genetics, Vol.17 No.2, pp. 121-126
Keywords
복합학foot diseasehallux valgusdeformity of footgenetic epidemiologytwin researchKoreansAsiatic races
Abstract
Hallux valgus (HV) is a common foot deformity of multifactorial etiology, but knowledge about the relative importance of genetics and environments on HV has been limited. In order to estimate genetic influences on HV, 1,265 adults, including 175 monozygotic twin (MZ) pairs, 31 dizygotic twin (DZ) pairs, and 853 first-degree singleton family members of the twins were included from the Healthy Twin study, a population-based twin-family cohort in Korea. All participants underwent foot examination and weight-bearing radiographic assessment (anterior-posterior and lateral) in addition to a general health survey. Of the subjects, 208 (16.4%) were classified as HV (as HV angle >20 degrees). The genetic influence on HV was estimated to be substantial; the heritability of HV was 0.51 (95% CI 0.42-0.59) and the heritability of HV angle was 0.47 (0.38-0.56), while contributions from shared environmental effects were negligible. These findings suggest that genetic factors play an important role in determining HV deformity.
ISSN
1832-4274
Language
English
URI
http://hdl.handle.net/10371/92537
DOI
https://doi.org/10.1017/thg.2014.10
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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