SHERP

수분 및 전해질 수지교란에 대한 신장의 반응
Renal Responses to the Changes in Volume and Osmolar Concentration of Extracellular Fluid

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Authors
김우겸; 안승운; 이종흔; 김기환; 엄융의; 김명철
Issue Date
1972-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1972;13(2):83-90
Abstract
Sixty-six healthy medical students were divided
into 5 groups and induced the changes in volume
and/or osmolar concentration of extracellular fluid:
The first group (water group) ingested 1.000ml
water; The second group (saline group) ingested
1.000 ml isotonic saline solution; The third group
(ADH group) ingested 600 ml water as a priming dose
and thereafter 200 ml water every 30 minutes. and
ADH(lOmU) was injected intramuscularly 2 hours
after the start of the experiment; The fourth group
(urea group) ingested 50 grams of urea; The fifth
group (beer group) ingested 1. 000 ml beer(4% ethyl
alcohol).
Urine was collected every 30 minutes. Urinary
volume. osmolarity and the excretion of sodium ions
were measured.
The results obtained are summerized as follows:
1. The water group showed that the urinary flow
begins to increase within 30 minutes and reached
its peak at 90 minutes after the start of the ex
periment. The total volume excreted for 2 hours
was approximately 1, 000ml. Urinary osmolaritγ and sodium ion concentration decreased almost
in proportion to the increase of urinary flow.
2. The saline group revealed that the diuresis was
moderate and greatly prolonged. The volume of
urine eliminated for 3 hours was less than 500
mI. Urinary osmolarity and especially sodium
ion concentration increased in parallel with the
increase of urinary flow.
3. The ADH group showed that the urinary flow
increased as the water group, but the decrement
of urinary flow rapidly developed within 30
minutes after ADH injection and the urinary
flow reached subnormal level 60 minutes after
the injection.
4. The urea group revealed that the changes in
urinary flow were in parallel with the changes
in solute, especially urea excretion. Maximal
urinary flow developed 45 minutes after the
start of the experiment and then decreased
gradually.
5. The beer group revealed that the pattern of the
urinary flow was similar to that of the water
group, but the volume of urine eliminated for
2 hours was more than that of the water group
(1. 100mI).
Language
Korean
URI
http://hdl.handle.net/10371/9262
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.2 (1972)
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