면역 반응기전을 중심으로한 비장의 조직학적 연구

Abstract

The spleens of human, ox, rabbits and rats were studied histologically. Serial sections of the tissues stained with methyl-green pyronin, Mallory-azan and Gridleys silver method were examined carefully in regarding to its architecture and staining nature of the composed cells. Pyronin-positive plasma cells were found to be localized at the periarteriallymphocyte sheath which surrounds the central arteries. The cells were more numerous at the terminal portion of the central arteries. Two distinct layers, the outer and the inner, were recognized and the apposed borders of each layer were separated by the reticular membrane which contains numerous marginal sinuses and capillaries. Composing cells of the marginal zone characterized by the small amount of pyroninophi1ic cytoplasm and lighter nucleus were different from the small lymphocytes and the macrophages. A nu ;nber of macrophages and rich capillaries were observed in the outer layer of the marginal zone. The so-called dark zone and the light zone of the g섬rminal center seemed to have constant direction of the arrangement, that is. the dark zone was located always near the central artery, while the light zone was far from the central artery. The possible invading route of the antigen in relation to the structures were discussed.