유간동내 산도 및 정체가 위산분비에 미치는 영향에 관한 실험적 연구

Abstract

In mongrel dogs with denervated total gastric pouch devided in two parts by a mucosal septum constructed at the junction of antral and fundic mucosa, the effect on acid output from fundic pouch in response to acidity and stasis of antral pouch perfusing with prepared stimulant solution of various pH was observed. The stimulant solution was prepared with O. 1% acetylcholine in saline. The pH of the solution was varied between 1. 0 and 8.0, using the stimulant mixture added with HCI or NaOH. When the stimulant solution of various pH was introduced into antral pouch for 3hr, 5hr, and 15hr period, the acid output from the fundic pouch was collected for 10hr or 15hr secretion , divided in 2 or 3 fractions of 5hr interval. By comparison of acid output (mEq) introduced each stimulant of various pH into antral pouch, optimal condition of pH was determined for release of gastrin from antrum. When the antral stasis was induced by the various pH solutions introduced into antral pouch for 5hrs or 15hrs, the amount(mEq) of acid output for 15hr period was compared in each case. Furthermore, in order to observe the phasic susceptibility of antral mucosa to various solutions, acid secretion for every 5hr interval was studied comparatively in case of the antral stasis for 15hrs. The results are as follows: 1. The antral phase of gastric secretion is most active at a pH of 6 and the optimal range of pH was 5 to 7. 2. The antral stasis with stimulant solution above level of pH 3 resulted in continuous secretion of acid. But the susceptibility of antral mucosa in response to each pH solution was almost constant in any fraction of 5hr intervals. 3. Acidification of the antrum below pH of 2 showed an inhibition of gastric acid secretion at the level of fasting.