급성실형시의 근력저하
Changes in the force of the muscular contraction in acute hemorrhagic hypotensive state

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권성락; 신동훈
Issue Date
서울대학교 의과대학
Seoul J Med 1975;16(2):120-129
Adults rabbits were subjected to bleeding to lower
their mean arterial blood pressure to 30-4j mmHg
in 15 minutes. The blood pressure was maintained
at a desired level by fixing the height of the
reservoir connected to the artery. The performance
of the gastrocnemius was studied at the hypotensive
state by taking the curves of tetanic contraction
before hemorrhage, at 30 minutes and at one hour
of hypotensive period. The peak of the tetanus
curve and the heights at 5 seconds and 10 seconds
were measured. AU values were expressed as the
ratio to the peak height of the curve which was
attained before the bleeding.
The animals were devided into 3 groups. They
were the control group, hemorrhage group and the
prednisolone treated group. In the hemorrhage
group the gastrocnemius muscles and sciatic nerves
of both sides were exposed and the strings attached
to the ends of the Achilles tendons were connected
to the transducers(myographs). Sciatic nerves were
cut and stimulating electrodes were placed on the
distal ends in order to get the tetanic contraction
curves of the gastrocnemius muscles. Immediately
aftee the surgical procedure blood was taken through
the canula inserted into the carotid artery, resulting
in a predetermined hypotensive state.
One of the gastrocnemius muscles was stimulated
during the hypotensive state every 3 seconds with
1-2 volts square wave of 2 milliseconds duration.
The opposite side was kept silent between the
consecutive tetanic contractions.
The animals of the prednisolone treated group
were given prednisolone. 25mgjkg. body weight
intraperitoneally one hour prior to the hemorrhage.
The control group was exempted from the hemor•
rhage. other surgical procedure being the same.
Concentrations of plasma sodium , potassium and
lactate were measured during the course. These
components and water content of the muscles were
also measured
The results obtained were as follows:
1. In the control group the surgical procedure
without hemorrhage brought deteriorations in the
performance of the muscle as well as in the chemical
components. Observations were limited to one hour
in the present studies.
2. In the silent muscles of the hemorrhaged
animals the performance was weakened progressive
Iy. In the active muscles which were stimulated
every 3 seconds during the hypotensive state, the
change in the performance and the alteration of the
chemical components were slight as comparing with
the resting muscles. Repeated contractions at a slow
rate seemed to bring beneficial effects on the
muscular function in these adverse conditions.
3. In the prednisolone treated group. the function
of the resting muscle was well preserved in the
hypotensive state. In the active muscle. however.
no improvement was noticed by the prednisolone
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 16 No.2 (1975)
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