Publications
Detailed Information
Bioelectronic Tongue Using Heterodimeric Human Taste Receptor for the Discrimination of Sweeteners with Human-like Performance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Jin, Hye Jun | - |
dc.contributor.author | Ahn, Sae Ryun | - |
dc.contributor.author | Kim, Daesan | - |
dc.contributor.author | Lee, Sang Hun | - |
dc.contributor.author | Kim, Un-Kyung | - |
dc.contributor.author | Simons, Christopher T. | - |
dc.contributor.author | Hong, Seunghun | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.creator | 박태현 | - |
dc.date.accessioned | 2015-06-19T06:22:04Z | - |
dc.date.available | 2015-06-19T06:22:04Z | - |
dc.date.created | 2018-07-09 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | ACS NANO, Vol.8 No.10, pp.9781-9789 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://hdl.handle.net/10371/94315 | - |
dc.description.abstract | The sense of taste helps humans to obtain information and form a picture of the world by recognizing chemicals in their environments. Over the past decade, large advances have been made in understanding the mechanisms of taste detection and mimicking its capability using artificial sensor devices. However, the detection capability of previous artificial taste sensors has been far inferior to that of animal tongues, in terms of its sensitivity and selectivity. Herein, we developed a bioelectronic tongue using heterodimeric human sweet taste receptors for the detection and discrimination of sweeteners with human-like performance, where single-walled carbon nanotube field-effect transistors were functionalized with nanovesicles containing human sweet taste receptors and used to detect the binding of sweeteners to the taste receptors. The receptors are heterodimeric G-protein-coupled receptors (GPCRs) composed of human taste receptor type 1 member 2 (hTAS1R2) and human taste receptor type 1 member 3 (hTAS1R3), which have multiple binding sites and allow a human tongue-like broad selectivity for the detection of sweeteners. This nanovesicle-based bioelectronic tongue can be a powerful tool for the detection of sweeteners as an alternative to labor-intensive and time-consuming cell-based assays and the sensory evaluation panels used in the food and beverage industry. Furthermore, this study also allows the artificial sensor to exam the functional activity of dimeric GPCRs. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Bioelectronic Tongue Using Heterodimeric Human Taste Receptor for the Discrimination of Sweeteners with Human-like Performance | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 송현석 | - |
dc.contributor.AlternativeAuthor | 진혜준 | - |
dc.contributor.AlternativeAuthor | 안세련 | - |
dc.contributor.AlternativeAuthor | 김대산 | - |
dc.contributor.AlternativeAuthor | 이상훈 | - |
dc.contributor.AlternativeAuthor | 김운경 | - |
dc.contributor.AlternativeAuthor | 홍승훈 | - |
dc.contributor.AlternativeAuthor | 박태현 | - |
dc.identifier.doi | 10.1021/nn502926x | - |
dc.citation.journaltitle | ACS NANO | - |
dc.identifier.wosid | 000343952600010 | - |
dc.identifier.scopusid | 2-s2.0-84908425639 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000002410/9 | - |
dc.description.srnd | SEQ:9 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000002410 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | DEPT_CD:458 | - |
dc.description.srnd | CITE_RATE:12.033 | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 9789 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 9781 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Seunghun | - |
dc.contributor.affiliatedAuthor | Park, Tai Hyun | - |
dc.identifier.srnd | 2014-01/102/0000002410/9 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | NANOTUBE HYBRID STRUCTURES | - |
dc.subject.keywordPlus | HUMAN OLFACTORY RECEPTOR | - |
dc.subject.keywordPlus | TIME-RESOLVED FRET | - |
dc.subject.keywordPlus | ELECTRONIC TONGUE | - |
dc.subject.keywordPlus | UMAMI TASTE | - |
dc.subject.keywordPlus | GPCR OLIGOMERIZATION | - |
dc.subject.keywordPlus | CONDUCTING POLYMERS | - |
dc.subject.keywordPlus | MAMMALIAN SWEET | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordAuthor | bioelectronic tongue | - |
dc.subject.keywordAuthor | human sweet taste receptor | - |
dc.subject.keywordAuthor | heterodimeric G-protein-coupled receptor | - |
dc.subject.keywordAuthor | single-walled carbon nanotube | - |
dc.subject.keywordAuthor | nanovesicle | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.