S-Space College of Medicine/School of Medicine (의과대학/대학원) Pediatrics (소아과학전공) Journal Papers (저널논문_소아과학전공)
Different recurrence rates between pediatric and adult renal transplant for immunoglobulin a nephropathy: Predictors of posttransplant recurrence
- Ahn, Sanghyun; Min, Sang-Il; Min, Seung-Kee; Ha, Il Soo; Kang, Hee Gyung; Kim, Yon Su; Kim, Sang Joon; Ha, Jongwon
- Issue Date
- Baskent University
- Experimental and Clinical Transplantation, vol.13 no.3, pp. 227-232
- Objectives: The purpose of this study was to investigate immunoglobulin A nephropathy recur-rence rate after transplant in children and adults and to identify recurrence rates by clinical progression before transplant.
Materials and Methods: There were 56 patients with immunoglobulin A nephropathy who had renal transplant between 1989 and 2005. We categorized recipient age into < or ≥ 20 years at transplant. Each age category was divided into 2 levels based on recurrence.
Results: The recurrence rate was higher in patients aged < 20 y (53.8%) than ≥ 20 y. Proteinuria was more frequently diagnosed in patients aged < 20 y (57.1% vs 25.0%; P = .047). In patients aged ≥ 20 y, the duration of dialysis was 4.55 mo in the recurrence group and 17.78 mo in the no recurrence group (P = .032). Time from progressive symptoms to renal replacement therapy was significantly shorter in patients aged ≥ 20 y with recurrence than patients aged ≥ 20 y with no recurrence. The univariate relative risk of recurrent immunoglobulin A nephropathy after transplant was 9.8 for recipients aged ≥ 20 y who had progressive symptoms to renal replacement therapy < 24 months (P = .046).
Conclusions: Patients aged < 20 y had more rapid disease progression to end-stage renal disease and a higher recurrence rate after transplant than patients aged ≥ 20 y. If patients aged ≥ 20 y progress rapidly from progressive symptoms to renal replacement therapy, renal transplant may be considered after 24 months because of high recurrence risk.
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