Computer Simulation of Optimal Insulin Profiles in Diabetic Patients
컴퓨터시뮬레이션 방법을 이용한 당뇨병 환자의 최적 인슐린 농도변화 형태 추정

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Youn, Jang Hyun; Lee, Hong-Kyu; Min, Byoung-Goo
Issue Date
서울대학교 의과대학
Seoul J Med 1981;22(4):541-545
Various types of the insulin delivery systems
have been used for the treatment of diabetic
patients to maintain the blood glucose level within
normal range (Slama et aL, 1974; Deckert
et aL, 1977; Genuth et aL, 1977; Bojsen et aL,
1978; Tambolane et aL, 1979). In utilizing
these systems, an optimal insulin infusion rates
and its patterns after meals are determined by
trial and error methods, as the required insulin
patterns are different from one patient to anothe
r. In these empirical methods,the endogenous
insulin delivery patterns of non-diabetic subjects
have been used as an initial reference information
, Then, by adjusting the insulin infusion rates
every day and evaluating the blood glucose
level , the final optimal insulin pattern is determined
when the glucose level remains within
normal range, This adjusting procedure usually
takes about one week in our clinical experience,
and other reported results(Genuth et aL,1977) ,
These results suggest that normal subject’s
insulin delivery pattern may not provide a
satisfying reference information in determining
the optimal insulin infusion pattern for diabetic
patients, For example, the same amount of
insulin has different effects on glucose control
in normal and diabetic groups, since each group has significantly different hepatic glucose balance
function and insulin resistivity at tissue
sites(Bergman et aL, 1974; Kimmerling et aL,
1976; Youn et aL, 1981)
Therefore, it is desirable to develop a quantitative
method of estimating the optimal insulin
infusion pattern rcquired to maintain glucose
level within nonnal range for a specific subject.
As a preliminary study of a ne찌 approach, we
will present a computer simulation method in
which the optimal plasma insulin concentration
profile after intravenous glucose loading is computed
from an analysis of the intravenous glucose
tolerance test (IVGTT) based on the equivalent
circuit model of the glucose kinetics (Youn et aL,
1981) .
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.4 (1981)
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