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Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols

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dc.contributor.authorShin, Hyoseungen
dc.contributor.authorCho, A-Ri-
dc.contributor.authorKim, Dong Young-
dc.contributor.authorMunkhbayer, Semchin-
dc.contributor.authorChoi, Soon-Jin-
dc.contributor.authorJang, Sunhyae-
dc.contributor.authorKim, Seong Ho-
dc.contributor.authorShin, Hyeon-Cheol-
dc.contributor.authorKwon, Ohsang-
dc.date.accessioned2016-02-01T01:03:22Z-
dc.date.available2016-02-01T01:03:22Z-
dc.date.issued2016-
dc.identifier.citationAnnals of Dermatology, vol.28 no.1, pp. 15-21-
dc.identifier.urihttp://hdl.handle.net/10371/95527-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.description.abstractBackground: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts. Objective: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. Methods: MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. Results: Treatment with 10 μg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30.3% more than in the negative control (p<0.001). Furthermore, 0.1 μg/ml PPE extended the human hair shaft 30.8% longer than the negative control over 9 days (p<0.05). Insulin-like growth factor-1 (IGF-1) mRNA expression increased 3.2-fold in hDPCs following treatment with 6 μg/ml PPE (p<0.05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2.0-fold by 3 μg/ml PPE (p<0.05). Treatment with 10 μg/ml PPE reduced oxidative stress in hDPCs (p<0.05). Conclusion: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.-
dc.language.isoen-
dc.publisherKorean Dermatological Association-
dc.publisherKorean Society for Investigative Dermatology-
dc.subjectEcklonia cava-
dc.subjectHair-
dc.subjectInsulin-like growth factor-I-
dc.subjectOxidative stress-
dc.subjectPolyphenols-
dc.subjectVascular endothelial growth factor A-
dc.titleEnhancement of Human Hair Growth Using Ecklonia cava Polyphenolsen
dc.typeArticle-
dc.contributor.AlternativeAuthor신효승-
dc.contributor.AlternativeAuthor조아리-
dc.contributor.AlternativeAuthor김동영-
dc.contributor.AlternativeAuthor최순진-
dc.contributor.AlternativeAuthor장선혜-
dc.contributor.AlternativeAuthor김성호-
dc.contributor.AlternativeAuthor신현철-
dc.contributor.AlternativeAuthor권오상-
dc.identifier.doi10.5021/ad.2016.28.1.15-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2016-01/102/0000045457/2-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A079130-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:1.393-
dc.description.srndFILENAME:ann dermatol 2016.pdf-
dc.description.srndDEPT_NM:의학과-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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