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Anti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC)

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Authors
Rahmawan, Yudi; Jang, Kyung-Jin; Moon, Myoung-Woon; Lee, Kwang-Ryeol; Suh, Kahp-Yang
Issue Date
2009-06-20
Publisher
한국바이오칩학회 = The Korean BioChip Society
Citation
Biochip J. 3, 143-150, 2009
Keywords
Diamond-Like Carbon (DLC)Cell adhesionSuperhydrophobicitySuperhydrophobicityDual-scale structureAnti-biofoulingCORONARY-ARTERY DISEASEBALLOON ANGIOPLASTYSOFT LITHOGRAPHYSURFACESTENTRESTENOSISENERGYPREVENTIONPROTEINSADHESION
Abstract
The textured surface with superhydrophobic nature was explored for an anti-biofouling template. Hierarchical structures composed of the nano-scale wrinkle covering on micro-scale polymer pillar patterns were fabricated by combining the deposition of a thin coating layer of biocompatible diamond-like carbon (DLC) and the replica molding of poly-(dimethylsiloxane) (PDMS) micro-pillars. The as-prepared surfaces were shown to have extreme hydrophobicity (static contact angle > 160 degrees) owing to low surface energy (24.2 mN/m) and dual-roughness structures of the DLC coating. It was explored that the hierarchical surfaces showed poor adhesion of the Calf Pulmonary Artery Endothelial (CPAE) cells for cultures of 7 days suggesting that the 3-dimensional (3-D) patterned superhydrophobic DLC coating exhibits excellent anti-biofouling properties against non-specific cell adhesion. In particular, the reduced filopodia extension during cell growth was caused by disconnected focal adhesions on the pillar pattern. This limited cell adhesion could prevent undesired growth and proliferation of biological species on the surface of biomedical devices such as stents, implants or even injection syringes.
ISSN
1976-0280
Language
English
URI
http://biochips.or.kr/

http://hdl.handle.net/10371/9556
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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