Stress시 시상하부-뇌하수체-부신계 조절에 대한 catecholamine 신경전달물질의 역할에 관한 연구
Roles of Catecholamines in the Regulation of Stress-induced Hypothalamo-Pituitary Adrenal(HPA) axis Stimulation

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서유헌; 임정규; 박찬웅
Issue Date
서울대학교 의과대학
Seoul J Med 1984;25(2):127-133
It is generally recognized that central nervous
1; ystem plays an essential role in the regulation
of synthesis and release of ACTH. It is now
firmly estabilished that the hypothalamus is the
focal point at which neural stimuli converge to
influence the secretion of ACTH, and the
median eminence is regarded as the final
common path through which information is
transmitted to the anterior pituitary.
In recent years, efforts have been directed
toward and progress has been made in identifying
some of the neurotransmitters that control
the release of corticotropin-releasing factor
(CRF). Among them, monoaminergic neural
systems in the hypothalmic control of pituitary
function have been widely studied.
A possible role of brain catecholamines in the
regulation of ACTH secretion has been con
sidered by numerous investigators. The cate
cholamines are not per se the hypothalamic
corticotropin releasing factors (Saffran and Schal1y,
1966; Guillemin and Rosenberg, 1965;
Martini et aI. , 1960; Fischer and Moriarty,
1977) .
Several groups of investigators have reported
increased adrenal corticosteroid secretion following the injection of catecholamines directly
into the brain (Endrocozi et aI. , 1963; Krieger
and Krieger, 1966).
On the other hand numerous studies have
failed to support an excitatory role of brain
catecholamines in the regulation of ACTH
secretion but have led to the opposite (Smelik,
1967; Carr and Moore , 1968; Van Loon et aI. ,
1971a,b,c; Scapagnini et aI. , 1970, 1971; Ganong
et aI., 1976; Ganong, 1977; Buckingham and
Hodges , 1977; Steiner and Grahame-Smith,
1980) .
This study was undertaken to try to clarify
the role of catecholamines (norepinephrine and
dopamine) in the hypothalamo-pituitary-adrenocortical
response to stress. Thε aims of the
present study ₩ere to check the kinetic parameters
of turnover of catecholamines as well
as steady state concentrations before and after
ether stress.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.2 (1984)
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