만성 간질환자에서의 혈중 인슐린, 24시간 뇨중 C-peptide와 적혈구 인슐린 수용체에 관한 연구

Abstract

Impaired glucose tolerance is a consistent finding of chronic liver disease and associated with hyperinsulinemia (Teng et aI. , 1980; Collins et aI., 1970). This finding implies insulin resistance. The exact mechanism of this impaired glucose tolerance and insulin resistance is, however, unclear. The present study was to understand at least a part of the pathogenic mechanism of this condition. To achieve this aim , we measured fasting and postprandial blood glucose , serum insulin as short-term insulin response, 24-hr urine C-peptide as an index of total daily insulin secretion amount, and total number and binding affinity of RBC insulin receptor as peri pheral insulin effect.