Effect of Regenerating Liver Cytosol on Liver Regeneration in Rats with Liver Cirrhosis

Abstract

The nature and origin of the regeneration promoting substances remain in dispute_ Portal blood factors have a specific effect on hepatic regeneration following partial hepatectomy_ 5t arzl et al (l973, 1979) proposed the multifactorial hypothesis. The pancreatic control was the most important, but the other nonhepatic splachnic organs did also some role in regeneration after partial hepatectomy in their experiment using the evisceration procedures. An additional question is whether they initiate regeneration or merely permit the process to proceed. While portal blood factors clearly influence hepatic regeneration, they may not initiate this process but merely play a permissive role (Bucher et aI. , 1978; Price , 1976). The actual genesis may start in the liver itself (Levi et aI. , 1971) . The interaction of factors that originate within the liver can contribute, regulate, or even initiate the actual development of liver regeneration after liver cell necrosis or partial hepatectomy. Labreque and Pesch(1975) demonstrated regenerative stimulator in the supernatant of an extract of rat liver mash. The regenerative stimulator was present not only in t 1984년 7월 9 일 접수 403 the liver mash of very young rat , but in the active regenerating remnant liver after partial hepatectomy in adult rat(LaBreque, 1979; Makowka, 1983). Liver cytosol fractions not only stimulate the rate of liver regeneration after partial hepatectomy in rats and dogs or after portacaval shunts in dogs(5tarzl et aI. , 1979) , but also after toxininduced hepatic necrosis (Makowka et aI. , 1981) and in a model of acute ethanol-induced inhibition of hepatic regeneration (Makowka, 1983). In acute hepatic failure this regenerating liver cytosol (RLC) dose the deliveratε enhancement or stimulation of regeneration in surviving or uninjured liver cells and the promotion of repair in the acutely damaged liver which has not respond with suitable or spontaneous regeneralion.