S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 25 No.3 (1984)
Effects of Hypoxia and/or Exercise on Pulmonary Epithelial Permeability
저산소 환경과 운동이 폐상피세포 투과성에 미치는 영향
- Kim, Kwang Woo
- Issue Date
- 서울대학교 의과대학
- Seoul J Med 1984;25(3):443-447
- The effect of hill walking in mountain area of
higher than 4, 000 meter recognized as pulmonary
edema, sodium retention, and increased plasma renin
and aldosterone activitives. To obtain evidences of
lung damages during hopoxic condition as mountain
area in FiO, 0.11 (4,000 meter in altitude) and
exercise we have measured changes in permeability
of the alveolar·capillary interface. The permeability
index was delivered from the half time clearance
from lung to blood (T~LB) of 09mTC-DTPA, inhaled
through mouth into lung by nebulizer in a 1ml bolus
7 persons with no smoking history (average 40 year
of age, 4 men and 3 women) were studied as foll'
1. Baseline T~LB values (control, A) were 60±2.64
(standard Deviation , S.D.) minutes which measured
in resting supine position and room air.
2. Initial hypoxia T~LB values were 49.8±3. 89(S.
D.) minutes which measured in resting supine po·
sition and FiO,O. 11 for 30 minutes and significantly
decreased than control value CA) (p<0.005), which
implied increased pulmonary epithelial permability.
3. Exercise·hypoxia T~LB values (e) were 29.8±2. 73
(S.D.) minutes which measured in FiO, 0.11 and
pedalling bicycle (Ergotest 4000) with supine posi·
tion and significantly decreased than initial hypoxia
value (B) (p<0.005) , which implied increased
pulmonary epithelial permeability.
4. Later hypoxia T~LB values (D) were 48.1±38
(S.D.) minutes which measured in resting supine
position and FiO, O. 11 for 30 minutes and markedly
increased than exercise hypoxic value (C) (p<
0.005) which implied improvement of pulmonary
epithelial permeability. Later control values (E)
were 57±2.64 (S.D.) minutes which measured in
resting supine position and room air. Baseline and
later control values were similier (p>O. l) .
5. Hypoxic condition and exercise migh induce to
increase 09mTc-DTPA permeability index of pul·
monary alveolar'capillary interface with unknown